Create new research programs aimed at understanding the integrative physiology of circadian rhythms and sleep and its impact on brain aging and the risk of AD and AD-related dementias at multiple levels (epigenetic, gene expression, proteomic, neuronal, network, systems) to identify new targets and approaches for AD prevention.
- Launch at least 12 new projects focused on understanding the short-term and long-term consequences of disrupted/optimized circadian rhythms and sleep on brain aging and dementia and the mechanistic links between sleep/circadian disruption and AD and AD-related dementias to identify new targets and approaches for AD prevention.
- Research Implementation Area
- Research on Disease Mechanisms
- In Progress
- PAR-18-497: Sleep disorders and circadian clock disruption in Alzheimer’s disease and other dementias of aging (R01)
- PAR-19-070: Research on Current Topics in Alzheimer's Disease and Its Related Dementias (R01 Clinical Trial Optional)
- RFA-AG-20-040: Oscillatory Patterns of Gene Expression in Aging and Alzheimer’s Disease (R01 Clinical Trial Not Allowed)
Research Programs and Resources
- Sleep disorders and circadian clock disruption in Alzheimer’s disease and other dementias of aging (R01) – 8 funded grants
- NIH Workshop (In Partnership with the Sleep Research Society): Developing Biomarker Arrays Predicting Sleep and Circadian-Coupled Risks to Health
- Alzheimer's Association International Conference (AAIC) Featured Research Session: Sleep in Alzheimer’s Disease; Molecules, Networks, People
- NIH Workshop: Neuropathological Impact of Sleep Deficiency and Sleep Disorders