Establish new research programs that employ data-driven, systems-based approaches to understand the interaction between peripheral systems (in particular: immune, metabolic, microbiome) and the brain and the impact of this interaction on brain aging and neurodegeneration. These efforts should integrate human and animal model research and characterize the extent to which molecular (epigenomic, transcriptomic and metabolomic) variation identified in peripheral tissues can be used as a proxy for inter-individual variation in the trajectories of brain aging, AD and AD-related dementias.
Launch at least 6 new research programs that use data-driven, systems-based approaches aimed at understanding the interaction between peripheral organ systems and the brain and the impact of this interaction on brain aging and neurodegeneration.
Provide support for studies that align blood and brain omics from longitudinal mouse and other pre-clinical models with human blood and brain omics to enable cross-species dynamic modeling of the trajectory of brain aging and disease progression.
- Research Implementation Area
- Research on Disease Mechanisms
- RFA-AG-15-010 Interdisciplinary Research to Understand the Vascular Contributions to Alzheimer's Disease (R01)
- RFA-AG-15-018: Immune and Inflammatory Mechanisms in Alzheimer’s Disease (R01)
- PAR-17-029: Dynamic Interactions between Systemic or Non-Neuronal Systems and the Brain in Aging and in Alzheimer’s Disease (R01)
- RFA-AG-17-051: Exosomes: From Biogenesis and Secretion to the Early Pathogenesis of Alzheimer's Disease (R01)
- RFA-AG-18-027: Exosomes: From Biogenesis and Secretion to the Early Pathogenesis of Alzheimer's Disease (R01)
- RFA-AG-17-055: Brain Lymphatic System in Aging and Alzheimer's Disease (R01)
- PAR-18-596: Research on Current Topics in Alzheimer's Disease and Its Related Dementias (R01)
- NOT-AG-18-001 (#6): Deciphering the Glycosylation Code of Alzheimer’s Disease
Research Programs and Resources
- NIA Workshop: Understanding the Role of the Microbiome in Aging and Age-Related Disorders