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Milestone 2.B

Establish new research programs that employ data-driven, systems-based approaches to understand the interaction between peripheral systems (in particular: immune, metabolic, microbiome) and the brain and the impact of this interaction on brain aging and neurodegeneration. These efforts should integrate human and animal model research and characterize the extent to which molecular (epigenomic, transcriptomic and metabolomic) variation identified in peripheral tissues can be used as a proxy for inter-individual variation in the trajectories of brain aging, AD and AD-related dementias.


Success Criteria

  • Launch at least 6 new research programs that use data-driven, systems-based approaches aimed at understanding the interaction between peripheral organ systems and the brain and the impact of this interaction on brain aging and neurodegeneration.

  • Provide support for studies that align blood and brain omics from longitudinal mouse and other pre-clinical models with human blood and brain omics to enable cross-species dynamic modeling of the trajectory of brain aging and disease progression.


Research Implementation Area
Research on Disease Mechanisms
Timeline
2016–2021
Status
Complete

Implementation Activities

Funding Initiatives

Research Programs and Resources

Research Highlights

Relevant Recommendations