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Disease Mechanisms: Exposome, iPSCs and animal models (Milestone 2.Y)

Support research that utilizes animal models of LOAD and iPSC-derived cerebral organoids from human donors, to understand the molecular mechanisms by which a variety of exposures (pathogens, toxicants, pollutants) influence the heterogeneity of AD/ADRD.

Success Criteria

  • Initiate at least one research program aimed at characterizing the impact of the exposome on the molecular, cellular, physiologic and neuropathologic aspects of AD/ADRD in animal models of LOAD (including polygenic animal models) and identifying surrogate measures of the impact of the exposome on brain aging and AD/ADRD in biosamples that can be obtained non-invasively.
  • This research should include studies that utilize systematic perturbation of iPSC-derived cerebral organoids from AD cases and controls, with a range of exogenous factors (i.e., pathogens, toxicants, pollutants, etc.) to characterize the molecular, cellular and neuropathological networks that are perturbed by each factor to enable the detection of shared, as well as distinct mechanism that are associated with different aspects of the exposome.
  • Ensure that all data and analytical outputs are made widely available according to open-science and FAIR data practice and encourage the adoption of exposomics-related ontologies for data interoperability.

Summary of Key Accomplishments

This milestone has yet to be initiated. Accomplishments are forthcoming.

This information is current as of July 2022.

Research Implementation Area
Research on Disease Mechanisms
To Be Initiated

Relevant Recommendations

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