Milestone 2.A
Create new research programs that use data-driven, systems-based approaches to integrate the study of fundamental biology of aging with neurobiology of aging and research on neurodegeneration, AD and AD-related dementias to better understand the mechanism(s) of vulnerability and resilience in AD across all levels of biologic complexity (from cellular to population level) and to gain a deeper understanding of the complex biology and integrative physiology of healthy and pathologic brain aging.
Success Criteria
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Launch at least 6 new research programs that use data-driven, systems-based approaches to integrate AD and ADRD research with the study of the fundamental biology of aging/neurobiology of aging.
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These programs should support studies that integrate epidemiologic, genomic, and basic research to understand: the dynamic interaction between aging and neurodegeneration mechanisms underlying individual differences in trajectories of brain aging, disease risk, age-of-onset, progression and clinical presentation.
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Ensure that these integrative research studies include under-represented, minority populations and patients with extreme phenotypes, atypical presentations of AD.
- Research Implementation Area
- Research on Disease Mechanisms
- Timeline
- 2016–2023
- Status
- In Progress
Accomplishments/Implementation Activities
Funding Initiatives
- RFA-AG-13-013: Interdisciplinary Approach to Identification and Validation of Novel Therapeutic Targets for Alzheimer's Disease (R01)
- PAR-14-281: Connectomes Related to Human Disease (U01)
- RFA-AG-14-002: Optogenetic Tools for the Study of Neural Systems in Aging and Alzheimer's Disease (R01)
- PAR-15-357: Understanding Alzheimer's Disease in the Context of the Aging Brain (R01)
- PAR-15-358: Capturing Complexity in the Molecular and Cellular Mechanisms Involved in the Etiology of Alzheimer’s Disease (R01)
- RFA-AG-15-010: Interdisciplinary Research to Understand the Vascular Contributions to Alzheimer's Disease (R01)
- RFA-AG-16-004: Lifespan Human Connectome Project: Aging (U01)
- PAR-17-047: Selective Cell and Network Vulnerability in Aging and Alzheimer’s Disease (R01)
- PAR-18-706: Selective Cell and Network Vulnerability in Aging and Alzheimer’s Disease (R01)
- RFA-AG-17-009: Impact of Aging in Human Cell Models of Alzheimer’s Disease (R01)
- RFA-AG-17-010: From Association to Function in the Alzheimer’s Disease Post-Genomics Era (R01)
- RFA-AG-18-026: From Association to Function in the Alzheimer’s Disease Post-Genomics Era (R01)
- RFA-AG-17-057: Systems Biology Approaches to Alzheimer’s Disease Using Non-mammalian Laboratory Animals (R01)
- RFA-AG-17-061: Interdisciplinary Research to Understand the Complex Biology of Resilience to Alzheimer’s Disease Risk
- RFA-AG-18-029: Interdisciplinary Research to Understand the Complex Biology of Resilience to Alzheimer’s Disease Risk
- PAR-18-596: Research on Current Topics in Alzheimer's Disease and Its Related Dementias (R01)
- NOT-AG-18-001 (#6): Deciphering the Glycosylation Code of Alzheimer’s Disease
- NOT-AG-18-001 (#9): Neuropsychiatric Symptoms in Alzheimer's Disease (NPS-AD)
- RFA-AG-18-021: Systems Biology Approaches using Non-Mammalian Laboratory Animals to Uncover Causes of Neurodegeneration that Might Underlie Alzheimer’s Disease and Related Dementias (R01)
- RFA-AG-18-023: Pathogenesis of Age-related HIV Neurodegeneration (R01)
- RFA-MH-19-510: Novel Mechanism Research on Neuropsychiatric Symptoms (NPS) in Alzheimer's Dementia (R01)
- RFA MH-19-511: Novel Mechanism Research on Neuropsychiatric Symptoms (NPS) in Alzheimer's Dementia (R21)
- PAR-17-038; reissued as PAR-18-029: Clarifying the Relationship between Delirium and Alzheimer’s Disease and Related Dementias (R01 Clinical Trial Optional)
- PAR-17-037; reissued as PAR-18-181: Clarifying the Relationship between Delirium and Alzheimer’s Disease and Related Dementias (R21/R33 Clinical Trial Optional)
- PAR-18-519: Sensory and Motor System Changes as Predictors of Preclinical Alzheimer’s Disease (R01)
- RFA-AG-19-027: A Census of Cells and Circuits in the Aging Brain (R01)
- RFA-AG-20-041: Regulation of Brain Regional and Cell Type Specific Proteome Dynamics in Alzheimer’s Disease (R21/R01)
- RFA-AG-20-042: Regulation of Brain Regional and Cell Type Specific Proteome Dynamics in Alzheimer’s Disease (R21/R01)
- RFA-AG-20-040: Oscillatory Patterns of Gene Expression in Aging and Alzheimer’s Disease (R01)
- RFA-AG-20-025: Understanding Senescence in Brain Aging and Alzheimer’s Disease (R01)
- RFA-AG-21-010: Glial Plasticity in the Aging Brain (R01)
Research Programs and Resources
- AMP AD Target Discovery and Preclinical Validation Project
- Molecular Mechanisms of the Vascular Etiology of Alzheimer's Disease (M²OVE-AD) Consortium
- NIH Blueprint for Neuroscience Research – Human Connectome Project
Research Highlights
- Workshop: Neuroscience Blueprint (BP) symposium on “Connectome Celebration: Human Connectome Project 2.0” (2016)
- Workshop: Role of Glycosylation and Carbohydrates in Aging and Early AD Pathogenesis (2018)
- Workshop: Disruptive Approaches to Understand the Initiation and Transmission of Misfolded Proteins in Alzheimer’s Disease (AD) (2016)
- Workshop: NIA/VA Partnership Meeting on Traumatic Brain Injury as Risk Factor for Alzheimer’s Disease (AD) and AD Related Dementias. Feb 26-27, 2019
- Workshop: Senescence in Brain Aging and Alzheimer’s Disease. September 18-19, 2019, Bethesda MD