Milestone 2.A

Create new research programs that use data-driven, systems-based approaches to integrate the study of fundamental biology of aging with neurobiology of aging and research on neurodegeneration, AD and AD-related dementias to better understand the mechanism(s) of vulnerability and resilience in AD across all levels of biologic complexity (from cellular to population level) and to gain a deeper understanding of the complex biology and integrative physiology of healthy and pathologic brain aging.

Success Criteria

  • Launch at least 6 new research programs that use data-driven, systems-based approaches to integrate AD and ADRD research with the study of the fundamental biology of aging/neurobiology of aging.

  • These programs should support studies that integrate epidemiologic, genomic, and basic research to understand: the dynamic interaction between aging and neurodegeneration mechanisms underlying individual differences in trajectories of brain aging, disease risk, age-of-onset, progression and clinical presentation.

  • Ensure that these integrative research studies include under-represented, minority populations and patients with extreme phenotypes, atypical presentations of AD.

Research Implementation Area
Research on Disease Mechanisms
Timeline
2016–2023
Status
In Progress

Implementation Activities

Funding Initiatives

Research Programs and Resources

Research Highlights

Relevant Recommendations