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Milestone 2.A

Create new research programs that use data-driven, systems-based approaches to integrate the study of fundamental biology of aging with neurobiology of aging and research on neurodegeneration, AD and AD-related dementias to better understand the mechanism(s) of vulnerability and resilience in AD across all levels of biologic complexity (from cellular to population level) and to gain a deeper understanding of the complex biology and integrative physiology of healthy and pathologic brain aging.


Success Criteria

  • Launch at least 6 new research programs that use data-driven, systems-based approaches to integrate AD and ADRD research with the study of the fundamental biology of aging/neurobiology of aging.

  • These programs should support studies that integrate epidemiologic, genomic, and basic research to understand: the dynamic interaction between aging and neurodegeneration mechanisms underlying individual differences in trajectories of brain aging, disease risk, age-of-onset, progression and clinical presentation.

  • Ensure that these integrative research studies include under-represented, minority populations and patients with extreme phenotypes, atypical presentations of AD.


Research Implementation Area
Research on Disease Mechanisms
Timeline
2016–2023
Status
In Progress

Accomplishments/Implementation Activities

Funding Initiatives

Research Programs and Resources

Research Highlights

Relevant Recommendations