Skip to main content
U.S. flag

An official website of the United States government

LBD: Understand Lewy body spreading and interactions with other AD/ADRD-related pathologies (Milestone 2.M)

In Progress

Timeline Start - End

2016 - 2027

Research Implementation Area

Research on Disease Mechanisms

AD-Related Dementias Focus

LBD Pathogenesis and Mechanisms of Toxicity: Identify mechanisms of selective vulnerability, disease heterogeneity, disease spread/propagation, and interaction with other age-related pathologies as therapeutic targets.

Success Criteria

  • At least one new project investigating α-synuclein spreading and α-synuclein interactions with other dementia-associated pathologies and how these interactions increase (or decrease) risk of symptomatic disease. 

  • At least two studies to understand why some brain cells are vulnerable to pathological alpha-synuclein accumulation while others are resistant.

Summary of Key Accomplishments

NINDS currently supports a Center Without Walls with four separate projects that are devoted to understanding devoted to understanding how the protein alpha-synuclein, which is often associated with LBD and Parkinson's disease, interacts with other AD/ADRD-related abnormal proteins, like beta-amyloid and tau, to initiate or accelerate brain disease in LBD. A request for applications (RFA NS21-006) was issued to invite research that seeks to understand how alpha-synuclein spreads and causes damage in the nervous system, and a number of applications were received and funded. Two recent research studies have shown that injecting alpha-synuclein into the brains of mice that carry gene mutations associated with Alzheimer's disease accelerates the rate at which beta-amyloid clumps deposit in the brain. These studies also show that abnormal deposits of tau and alpha-synuclein increase and brain inflammation increases.

The key accomplishments summary is current as of July 2022.  

Accomplishments/Implementation Activities

Funding Initiatives

Research Programs and Resources

Relevant Recommendations

Related Milestones

Search all Research Categories

An official website of the National Institutes of Health