Skip to main content
U.S. flag

An official website of the United States government

Disease Mechanisms: Social and psychosocial factors (Milestone 2.J)

In Progress

Timeline Start - End

2018 - 2024

Research Implementation Area

Research on Disease Mechanisms

Expand research on the role of social and psychosocial factors on AD risk and resilience to risk in ethnically and socioeconomically diverse populations to interrogate mechanisms of disparities in health burden of AD, and inform intervention strategies and public health policy. These efforts should utilize a life-course approach.

Success Criteria

  • Initiate at least 6 research projects focused on understanding heterogeneous mechanistic pathways of disparities in health burden of AD, testing whether causal pathways to AD differ across disparities populations and identifying critical windows of vulnerability to AD risk.

Summary of Key Accomplishments

To support our understanding of the causes of AD across populations, NIA issued a funding opportunity to gather new cognitive measures through the Midlife in the U.S. (MIDUS) study. Funded projects will leverage existing non-AD cohorts to understand the behavioral, social, psychological, biological, and environmental risk and protective factors for dementia. NIA also supports a new research network, the Network for Emotional Wellbeing (NEW) and Brain Aging Center, examining how brain aging impacts emotional well-being and risk for progression of AD/ADRD.

The Health and Retirement Study (HRS) has expanded to include additional minority participants across their age cohorts, providing an opportunity to implement the Harmonized Cognitive Assessment Protocol (HCAP) to assess dementia risk across diverse populations. NIA also supports demographically diverse educational cohort studies, including Add Health and High School and Beyond, seeking to elucidate how education and other social factors affect risk and protective factors for dementia across the life course.

The key accomplishments summary is current as of March 2022. 

Accomplishments/Implementation Activities

Funding Initiatives

Research Programs and Resources

Research Highlights

Relevant Recommendations

Related Milestones

Search all Research Categories

An official website of the National Institutes of Health