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Disease Mechanisms: Common mechanisms (Milestone 2.H)

In Progress

Timeline Start - End

2018 - 2024

Research Implementation Area

Research on Disease Mechanisms

Continue to support cross-disciplinary research to discover and understand disease mechanisms that are common between AD and other neurodegenerative disorders including rare disorders and leverage these for therapy development. These efforts should include discovering new pathways leading to synaptic and neural damage understanding the structural variations of pathogenic peptides collected from well-phenotyped, diverse cohorts to inform the design of structure-specific imaging agents and inhibitors with therapeutic potential.

Success Criteria

  • Identify and preclinically validate at least three novel therapeutic targets that are common to AD and at least two other neurodegenerative disorders. 
  • Launch a minimum of three drug discovery projects targeting pathways common across AD at least two other neurodegenerative disorders.

Summary of Key Accomplishments

NIA supports research aimed at understanding disease mechanisms that are common between AD and other neurodegenerative disorders. This is achieved through one targeted funding initiative, other broad funding initiatives, and via investigator-initiated research. Six projects have been supported through the targeted funding initiative Common Mechanisms and Interactions Among Neurodegenerative Diseases. Collectively, these projects investigate the shared mechanisms among AD, Parkinson’s, Lewy body dementia and Huntington’s disease. The insights from this program have the potential to identify novel shared targets for multiple disorders.

The key accomplishments summary is current as of March 2022. 

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