Disease Mechanisms

Create new research programs that use data-driven, systems-based approaches to integrate the study of fundamental biology of aging with neurobiology of aging…

Establish new research programs that employ data-driven, systems-based approaches to understand the interaction between peripheral systems (in particular: immune, metabolic, microbiome) and the brain

Create research programs on epigenetics to understand how genetic and environmental factors interact across the lifespan to influence brain aging…

Create programs in basic, translational and clinical research aimed at comprehensive understanding of the impact of sex differences on the trajectories of brain aging…

Create cross-disciplinary research programs aimed at understanding the integrative physiology of APOE…

Create new research programs aimed at understanding the integrative physiology of circadian rhythms and sleep…

Maximize the translational potential of genetics research by ensuring rapid and broad sharing of large-scale genetic/genomic data...

Continue to support cross-disciplinary research to discover and understand disease mechanisms...

Enable a system biology approach to decipher the complex role of the microbiome in brain aging and AD/ADRD...

Expand research on the role of social and psychosocial factors, on AD risk and resilience to risk in ethnically and socioeconomically diverse populations...

Create new research programs that use data-driven, network biology approaches aimed at understanding the (epi)genetics and complex biology of cognitive resilience...

Support research to evaluate the role of the microbiome on the impact of diet on AD risk/resilience.

Support research that utilizes animal models of LOAD and iPSC-derived cerebral organoids from human donors, to understand the molecular mechanisms by which a variety of exposures (pathogens, toxicants

Promote basic and clinical research in multi-etiology dementia.

Develop LBD animal, cellular, and in vitro models that recapitulate key features, including clinical pathophysiologic heterogeneity to identify mechanistic candidates for interventions.

Clarify the mechanism of tau pathogenesis and associated neurodegeneration.

Determine the molecular basis for C9ORF72 expansion-and GRN mutation-related neurodegeneration.

Determine the mechanism of TDP-43 and FUS pathogenesis and toxicity.

Encourage basic science research that investigates the impact of aging, AD pathology, and genes on peri- and para-vascular clearance mechanisms, the NVU, and cerebrovascular function.

Encourage basic science research that investigates the impact of cerebrovascular risk factors/genes and atherosclerosis on AD-related neurodegeneration.

Determine interrelationships among aging, cerebrovascular disease and risk factors, resilience factors, genetic variants, amyloid, tau, and neurodegeneration.

Understanding the molecular, cellular and α-synuclein in the context of non-motor brain areas.

Determine underlying pathobiologic and molecular mechanisms of cellular TDP-43 displacement, post-translational modifications such as phosphorylation, and pathology in pre-symptomatic and manifest

Examine the pathologic phenotype(s) of TDP-43 pathology in asymptomatic persons and those with common dementias.

Promote basic and clinical research examining the development and progression of TBI AD/ADRD neuropathologies and associated clinical symptoms.