Skip to main content
U.S. flag

An official website of the United States government

Disease Mechanisms Milestones

2.A-2.CC

Selected filters

No filters selected

Filter
29 Results

ID

Title

Status

Create new research programs that use data-driven, systems-based approaches to integrate the study of fundamental biology of aging with neurobiology of aging…

Status

Achieved

Establish new research programs that employ data-driven, systems-based approaches to understand the interaction between peripheral systems (in particular: immune, metabolic, microbiome) and the brain…

Status

Achieved

Create research programs on epigenetics to understand how genetic and environmental factors interact across the lifespan to influence brain aging…

Status

Achieved

Create programs in basic, translational and clinical research aimed at comprehensive understanding of the impact of sex differences on the trajectories of brain aging…

Status

Achieved

Create cross-disciplinary research programs aimed at understanding the integrative physiology of APOE…

Status

Achieved

Create new research programs aimed at understanding the integrative physiology of circadian rhythms and sleep…

Status

Achieved

Maximize the translational potential of genetics research by ensuring rapid and broad sharing of large-scale genetic/genomic data...

Status

Achieved

Continue to support cross-disciplinary research to discover and understand disease mechanisms...

Status

In Progress

Enable a system biology approach to decipher the complex role of the microbiome in brain aging and AD/ADRD...

Status

Achieved

Expand research on the role of social and psychosocial factors, on AD risk and resilience to risk in ethnically and socioeconomically diverse populations...

Status

In Progress

Create new research programs that use data-driven, network biology approaches aimed at understanding the (epi)genetics and complex biology of cognitive resilience...

Status

Achieved

Promote basic and clinical research in multi-etiology dementia.

Status

In Progress

Develop LBD animal, cellular, and in vitro models that recapitulate key features, including clinical pathophysiologic heterogeneity to identify mechanistic candidates for interventions.

Status

In Progress

Clarify the mechanism of tau pathogenesis and associated neurodegeneration.

Status

In Progress

Determine the molecular basis for C9ORF72 expansion-and GRN mutation-related neurodegeneration.

Status

In Progress

Determine the mechanism of TDP-43 and FUS pathogenesis and toxicity.

Status

In Progress

Encourage basic science research that investigates the impact of aging, AD pathology, and genes on peri- and para-vascular clearance mechanisms, the NVU, and cerebrovascular function.

Status

In Progress

Encourage basic science research that investigates the impact of cerebrovascular risk factors/genes and atherosclerosis on AD-related neurodegeneration.

Status

In Progress

Determine interrelationships among aging, cerebrovascular disease and risk factors, resilience factors, genetic variants, amyloid, tau, and neurodegeneration.

Status

In Progress

Understanding the molecular, cellular and α-synuclein in the context of non-motor brain areas.

Status

In Progress

Determine underlying pathobiologic and molecular mechanisms of cellular TDP-43 displacement, post-translational modifications such as phosphorylation, and pathology in pre-symptomatic and manifest common dementias.

Status

In Progress

Examine the pathologic phenotype(s) of TDP-43 pathology in asymptomatic persons and those with common dementias.

Status

In Progress

Promote basic and clinical research examining the development and progression of TBI AD/ADRD neuropathologies and associated clinical symptoms.

Status

In Progress

Support research to evaluate the role of the microbiome on the impact of diet on AD risk/resilience.

Status

In Progress

Support research that utilizes animal models of LOAD and iPSC-derived cerebral organoids from human donors, to understand the molecular mechanisms by which a variety of exposures (pathogens, toxicants, pollutants) influence the heterogeneity of AD/ADRD.

Status

In Progress

Identify overlapping pathogenic mechanisms between FTD and other neurodegenerative disorders and syndromes.  

Status

In Progress

Elucidate the mechanisms of cell type vulnerability and cell-intrinsic and –extrinsic effects on FTD pathogenesis, with the goal of accelerating development of therapeutic targets.  

Status

In Progress

TDP-43 in AD/ADRD: Understanding mechanisms and relationships to other diseases

Status

In Progress

Understanding AD/ADRD brain changes after COVID-19

Status

In Progress

Search all Research Categories

nia.nih.gov

An official website of the National Institutes of Health