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TDP-43 in AD/ADRD: Establish biomarkers and dementia risk profiles (Milestone 9.T)

In Progress

Timeline Start - End

2020 - 2030

Research Implementation Area


AD-Related Dementias Focus

Develop biomarkers, classifiers, and risk profiles to establish in-vivo diagnostic criteria for LATE in persons without cognitive symptoms and in persons with amnestic or other relevant late-life dementia syndromes, assuring diversity, inclusion and equity.

Success Criteria

  • At least three new projects to develop biomarker profiles for clinical trials for TDP-43 proteinopathy in common dementias.

Summary of Key Accomplishments

Currently, biomarkers that reveal pathological changes in TDP-43, a protein linked to various types of dementia, are needed across all stages of disease. NIH supports multiple funding opportunities to develop biomarkers for TDP-43 neuropathology. Recently, researchers showed that detection of extremely low levels of TDP-43 may be overcome by technological advances to amplify TDP-43 from cerebral spinal fluid or isolate it from plasma. Additionally, NIH supports the National Centralized Repository for Alzheimer’s Disease and Related Dementias (NCRAD), which is a repository for biological specimens available to researchers to help identify disease genes and support biomarker development for AD/ADRDs, including for TDP-43.

The key accomplishments summary is current as of July 2022.

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