Multiple Etiology Dementias: Support research on early detection of cognitive impairment/dementia in everyday settings (Milestone 9.K)
Timeline Start - End2016 - 2027
Research Implementation AreaBiomarkers
AD-Related Dementias Focus
Evaluate pragmatic approaches to objectively detect cognitive impairment and link to quality care when a patient, care partner, or clinician reports cognitive, behavioral, or functional changes.
- Complete at least three clinical trials to validate assessment paradigms to detect cognitive impairment in large and diverse populations in primary care practice and other every day clinical care settings.
Summary of Key Accomplishments
DetectCID (RFA-NS-17-012 & RFA-NS-22-009) is improving the quality of patient evaluations for detecting cognitive impairment in everyday clinical settings. For example, researchers created a new set of easy-to-use, 5-minute screening tools designed for use across languages and cultures. The UCSF Brain Health Assessment has developed and validated a 10 minute, tablet-based system to differentially diagnose different types of mild cognitive impairment. The NIH has also invested in research and validation of mobile tools for detection of cognitive impairment under RFA-AG-18-012 and started to validate them in existing cohorts. These efforts are on on-going, pivoting to a focus on pragmatic clinical trials.
The key accomplishments summary is current as of July 2022.
- RFA-NS-17-012: Detecting Cognitive Impairment, Including Dementia, in Primary Care and Other Everyday Clinical Settings for the General Public and in Health Disparities Populations (UG3/UH3)
- RFA-NS-22-009: Detecting Cognitive Impairment, Including Dementia, in Primary Care and Other Everyday Clinical Settings for the General Public and Health Equity, Pragmatic Clinical Trials (U01 Clinical Trial Required)
Research Programs and Resources
- Precision Aging Network: Closing the Gap Between Cognitive Healthspan and Human Lifespan
- Select projects funded in FY22
- 2016 ADRD Summit: Multiple Etiology Dementias (MED) Focus Area 1: Improved Diagnostic Skills in the Community, Recommendation 1
- 2022 ADRD Summit: Multiple Etiology Dementias (MED) Milestone 1, Priority 1