Skip to main content
U.S. flag

An official website of the United States government

Multiple Etiology Dementia: Implement interventions for reversible causes (Milestone 11.L)

In Progress

Timeline Start - End

2020 - 2030

Research Implementation Area

Enabling Technologies and Disease Monitoring

AD-Related Dementias Focus

Conduct clinical studies on approved or promising interventions and treatments to mitigate risk for cognitive decline.

Success Criteria

  • Initiate at least one real-world clinical practice setting study on approved or promising interventions and treatments in hospital and community-based settings that targets risk factors for cognitive decline.
  • Establish a national research consortium to develop, test, refine, implement, and disseminate best practices for determining whether reversible risks and causes of cognitive dysfunction are present in an individual, and how to facilitate successful intervention.

Summary of Key Accomplishments

Several ongoing NIH-funded research studies are assessing non-pharmacologic interventions to reduce the risk of developing AD/ADRDs, including multi-component interventions that target lifestyle factors like diet, exercise, cognitive training, and blood pressure control. For example, the U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (U.S. POINTER), primarily funded by the Alzheimer's Association and also supplemented with NIA funding, is a clinical trial to evaluate whether lifestyle interventions that simultaneously target many risk factors protect cognitive function in older adults who are at increased risk for cognitive decline (; estimated completion is December 2024. The NINDS's Mind Your Risks campaign is directly focused on educating and empowering individuals with, or at risk of, high blood pressure to take control of their health and lower their risk of having a stroke or developing dementia later in life. Materials are being developed that can be used in clinical care settings to help individuals and clinicians talk about how risky high-blood pressure can be controlled and monitored.

The key accomplishments summary is current as of July 2022.

Accomplishments/Implementation Activities

Funding Initiatives

Research Programs and Resources

Research Highlights

Relevant Recommendations

Related Milestones

Search all Research Categories

An official website of the National Institutes of Health