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Milestone 9.T

AD Related Dementias – Specific

Develop biomarker and risk profiles to establish in-vivo diagnostic criteria for TDP-43 pathology in persons without cognitive symptoms and in persons with amnestic syndromes, e.g. amnestic MCI and AD clinical syndrome.

Success Criteria

  • Support research to develop biomarker and/or risk profiles designed to facilitate clinical trial stratification for TDP-43 proteinopathy in common dementias.

Summary of Key Accomplishments

Currently, biomarkers that reveal pathological changes in TDP-43, a protein linked to various types of dementia, are needed across all stages of disease. NIH supports multiple funding opportunities to develop biomarkers for TDP-43 neuropathology. Recently, researchers showed that detection of extremely low levels of TDP-43 may be overcome by technological advances to amplify TDP-43 from cerebral spinal fluid or isolate it from plasma. Additionally, NIH supports the National Centralized Repository for Alzheimer’s Disease and Related Dementias (NCRAD), which is a repository for biological specimens available to researchers to help identify disease genes and support biomarker development for AD/ADRDs, including for TDP-43.

This information is current as of July 2022.

Research Implementation Area
AD Related Dementias - Specific
In Progress

Accomplishments/Implementation Activities

Funding Initiatives

Research Programs and Resources

Relevant Recommendations

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