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Milestone 9.S

AD Related Dementias – Specific

Advance FTD clinical trial design and execute new prevention and treatment studies.

Success Criteria

  • Support a research registry for FTD clinical studies that includes underserved and minority group representation reflecting population demographics.
  • Develop standardized protocols for prevention studies of familial FTD syndromes or clinical trials in symptomatic, sporadic, and familial FTD.
  • Support clinical trials of novel FTD therapeutics.

Summary of Key Accomplishments

The FTD Disorders Registry is a contact and research registry supported by patient advocacy groups and is open to all with particular interest in including underserved and minority groups and is well-integrated into the large ALLFTD natural history study (AG063911). The development of standardized protocols is proceeding also through the ALLFTD natural history study and collaborating FTD Prevention Initiative (FPI - with the refinement of outcome measures and the establishment of which of these outcome measures are most sensitive and useful for which subtype of FTD. The NIH also continues to support clinical trials in FTD, particularly early stage studies looking at novel interventions such as neuromodulation including transcranial direct stimulation and small molecules to target toxic reactive oxygen species.

This information is current as of July 2022.

Research Implementation Area
AD Related Dementias - Specific
In Progress

Accomplishments/Implementation Activities

Funding Initiatives

Research Programs and Resources

Relevant Recommendations

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