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Milestone 9.R

AD Related Dementias – Specific

Develop, validate and longitudinally track: (i) cognitive, physical, or other functional assessment components that indicate the presence of VCID, (ii) VCID biomarkers, including when VCID is accompanied by pathological AD.

Success Criteria

  • Support human-based research to identify imaging and fluid-based biomarkers that, together with appropriate cognitive and clinical measures (examples to consider, but not limited to locomotion, heart function, metabolic measures, and kidney function), indicate the presence (or absence), type, severity, and progression of small vessel VCID in at least two human cohorts.
  • Establish a direct link from in vivo VCID biomarker measures (including appropriate cognitive and clinical measures) to ex vivo imaging to histopathology. 

Summary of Key Accomplishments

Until recently, diagnosis of brain arteriolosclerosis, which is one of the main pathologies of cerebral small vessel disease that is known to contribute to cognitive decline and dementia, was only possible at autopsy. Through the NIH funded MarkVCID consortium, researchers have developed an assessment that combines MRI pictures of the brain taken with other factors such as age and gender to measure arteriolosclerosis. Known as ARTS, this new biomarker is associated with increased chance of cognitive decline two-years later and shows good performance in predicting disease. Current work is focused on clinically validating this biomarker, including in Black and Hispanic populations, for use in future clinical trials and for generating scientific breakthroughs in understanding and treating small vessel vascular contributions to cognitive impairment and dementia (VCID).

This information is current as of July 2022.

Research Implementation Area
AD Related Dementias - Specific
In Progress

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