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Milestone 9.M

AD Related Dementias – Specific

Develop diagnostics/biomarkers in asymptomatic individuals.

Success Criteria

Develop at least one improved imaging or fluid biomarker for AD, cerebrovascular disease (including the health of the neurovascular unit), and each of the ADRDs, to estimate future risk for cognitive impairment in asymptomatic individuals.

Conduct one or more studies that validate diagnostic and theragnostic utility of new biomarkers in asymptomatic populations, especially in minority groups and in middle age using population-based studies. Include evaluation of the relative clinical importance of different etiologies when more than one etiology is present.

Summary of Key Accomplishments

Commercial products to measure Aβ40/42 in blood (C2N) and the cerebrospinal fluid (Quest Diagnostic) can identify high-risk pre-symptomatic individuals, though there is scientific debate about its reliability for clinical applications. PET imaging markers allow for estimation of future risk for cognitive impairment in asymptomatic individuals. These have been evaluated in proteinopathy consortium (CW2IP2): PM-PBB3 and CBD-2115 (4R-tau) and alpha-synuclein but are not yet commercially viable. The NIH continues to fund research into biomarkers capable of quantifying dementia risk with greater precision and reliability.

This information is current as of July 2022.

Research Implementation Area
AD Related Dementias - Specific
In Progress

Relevant Recommendations

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