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Milestone 9.K

AD Related Dementias – Specific

Detect whether cognitive impairment is objectively present when a patient, care partner or clinician reports cognitive, behavioral or functional changes.


Success Criteria

  • Support at least two research programs to develop and validate assessment paradigms that address the unmet need to detect cognitive impairment and dementia in large and diverse populations seen in primary care practice and other every day clinical care settings, including in non-English speaking settings.
  • Evaluate the success of the resulting paradigms for:
    • Coverage of both general and diverse populations in the U.S., including via engagement of local communities in the development of community and culturally informed paradigms.
    • The extent to which validated paradigms are reimbursable, time efficient, with easily interpreted results, and useful in diverse primary care settings.
    • The extent to which the paradigms include provider guidance for appropriate follow-up, including specialty referrals and caregiver support.
    • The extent to which the paradigms have training materials suitable for both physicians and non-physician medical personnel who administer them.
    • The extent to which the paradigms are readily accessible and to which there is uptake by both primary caregivers and researchers.

Summary of Key Accomplishments

DetectCID (RFA-NS-17-012 & RFA-NS-22-009) is improving the quality of patient evaluations for detecting cognitive impairment in everyday clinical settings. For example, researchers created a new set of easy-to-use, 5-minute screening tools designed for use across languages and cultures. The UCSF Brain Health Assessment has developed and validated a 10 minute, tablet-based system to differentially diagnose different types of mild cognitive impairment. The NIH has also invested in research and validation of mobile tools for detection of cognitive impairment under RFA-AG-18-012 and started to validate them in existing cohorts. These efforts are on on-going, pivoting to a focus on pragmatic clinical trials.

This information is current as of July 2022.


Research Implementation Area
AD Related Dementias - Specific
Timeline
2016–2023
Status
In Progress

Accomplishments/Implementation Activities

Funding Initiatives

Research Programs and Resources

Research Highlights

Relevant Recommendations

nia.nih.gov

An official website of the National Institutes of Health