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Biomarkers: Biomarkers for target engagement (Milestone 9.C)

Initiate development of imaging and/or fluid biomarkers to demonstrate target engagement for 5 novel therapeutic targets for AD and AD-related dementias.


Success Criteria

Identification of 3 imaging and/or fluid biomarkers for which there is proof of engagement of novel therapeutic targets.

Summary of Key Accomplishments

NIA supports biomarker discovery by academic institutions and small biotech companies through targeted and non-targeted funding initiatives. Seven new imaging biomarkers (five PET ligands and two MRI-based markers) reflecting synaptic function, oxidative stress, and neuroinflammation are being developed and evaluated in animal models and in humans. In addition, 28 projects have been funded that support the discovery of novel blood-based biomarkers using various genomic technologies.

This information is current as of March 2022.


Research Implementation Area
Biomarkers
Timeline
2014–2024
Status
In Progress

Accomplishments/Implementation Activities

Funding Initiatives

Research Programs and Resources

Research Highlights

Relevant Recommendations

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An official website of the National Institutes of Health