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Biomarkers: Biomarkers for preclinical/clinical drug development (Milestone 9.A)

Develop and validate translatable biomarkers for their use in preclinical and clinical drug development. These efforts should include the development of pharmacodynamic biomarkers of target engagement, biomarkers of incipient disease (ocular, olfactory) and biomarkers for detection and tracking of synaptic dysfunction.


Success Criteria

Develop and validate at least 12 translatable biomarkers for use in preclinical and clinical drug development.

Summary of Key Accomplishments

Through the NIA-supported MODEL-AD Centers, researchers are developing translatable biomarkers that can be used in preclinical and clinical drug development. The Centers are developing new mouse models for late-onset AD and are conducting detailed characterization of the most promising models; this includes a collaboration with the Accelerating Medicines Partnership for AD (AMP AD) focused on comparing the molecular signatures from brain and blood samples between the mouse models of late onset AD and people living with AD.

This information is current as of July 2022.


Research Implementation Area
Biomarkers
Timeline
2016–2024
Status
In Progress

Accomplishments/Implementation Activities

Funding Initiatives

Research Programs and Resources

Research Highlights

Relevant Recommendations

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