AD Related Dementias – Specific
Conduct intervention studies to mitigate reversible causes of cognitive dysfunction in persons with or at-risk for cognitive impairment and dementia of aging where etiology may be uncertain or where multiple etiologies appear likely.
- Establish a national research consortium to perform applied research to test, refine and implement, in primary care and other everyday care settings, effective paradigms for determining whether reversible causes of cognitive dysfunction are present in an individual, and if so, how to facilitate successful intervention.
- Develop and disseminate best practices for primary care and other everyday care settings for determining whether reversible causes of cognitive dysfunction are present in an individual.
Summary of Key Accomplishments
Several ongoing NIH-funded research studies are assessing non-pharmacologic interventions to reduce the risk of developing AD/ADRDs, including multi-component interventions that target lifestyle factors like diet, exercise, cognitive training, and blood pressure control. For example, the U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (U.S. POINTER), primarily funded by the Alzheimer's Association and also supplemented with NIA funding, is a clinical trial to evaluate whether lifestyle interventions that simultaneously target many risk factors protect cognitive function in older adults who are at increased risk for cognitive decline (https://alz.org/us-pointer/overview.asp); estimated completion is December 2024. The NINDS's Mind Your Risks campaign is directly focused on educating and empowering individuals with, or at risk of, high blood pressure to take control of their health and lower their risk of having a stroke or developing dementia later in life. Materials are being developed that can be used in clinical care settings to help individuals and clinicians talk about how risky high-blood pressure can be controlled and monitored.
This information is current as of July 2022.
- Research Implementation Area
- AD Related Dementias - Specific
- In Progress
- RFA-NS-19-012: Post-Stroke Vascular Contributions to Cognitive Impairment and Dementia (VCID) in the United States Including in Health Disparities Populations (U19)