Skip to main content
U.S. flag

An official website of the United States government

Milestone 11.L

AD Related Dementias – Specific

Conduct intervention studies to mitigate reversible causes of cognitive dysfunction in persons with or at-risk for cognitive impairment and dementia of aging where etiology may be uncertain or where multiple etiologies appear likely.

Success Criteria

  • Establish a national research consortium to perform applied research to test, refine and implement, in primary care and other everyday care settings, effective paradigms for determining whether reversible causes of cognitive dysfunction are present in an individual, and if so, how to facilitate successful intervention.
  • Develop and disseminate best practices for primary care and other everyday care settings for determining whether reversible causes of cognitive dysfunction are present in an individual.

Summary of Key Accomplishments

Several ongoing NIH-funded research studies are assessing non-pharmacologic interventions to reduce the risk of developing AD/ADRDs, including multi-component interventions that target lifestyle factors like diet, exercise, cognitive training, and blood pressure control. For example, the U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (U.S. POINTER), primarily funded by the Alzheimer's Association and also supplemented with NIA funding, is a clinical trial to evaluate whether lifestyle interventions that simultaneously target many risk factors protect cognitive function in older adults who are at increased risk for cognitive decline (; estimated completion is December 2024. The NINDS's Mind Your Risks campaign is directly focused on educating and empowering individuals with, or at risk of, high blood pressure to take control of their health and lower their risk of having a stroke or developing dementia later in life. Materials are being developed that can be used in clinical care settings to help individuals and clinicians talk about how risky high-blood pressure can be controlled and monitored.

This information is current as of July 2022.

Research Implementation Area
AD Related Dementias - Specific
In Progress

Accomplishments/Implementation Activities

Funding Initiatives

Research Programs and Resources

Relevant Recommendations

An official website of the National Institutes of Health