Enabling Tech: Outcome measures harmonization (Milestone 11.B)
Timeline Start - End2018 - 2024
Research Implementation AreaEnabling Technologies and Disease Monitoring
Continue to develop standard outcome measures to enable data comparisons across studies, including but not limited to cognitive functioning and physical function and ensure that these measures are validated across a variety of educational, linguistic, and cultural groups.
Develop criteria and methods for screening, testing, and validating new technologies for disease monitoring.
Launch at least one large longitudinal study evaluating the validity of standard outcome measures across three or more diverse groups. The study should be sufficiently powered to enable the validation of each of the outcome measures within each of the diverse groups.
Summary of Key Accomplishments
NIA supported the development of a state-of-the-art protocol for assessing dementia in large nationally representative samples – called the Harmonized Cognitive Assessment Protocol (HCAP) – which is now being implemented in the NIA-funded Health and Retirement Study and multiple international sister studies to facilitate cross-country comparisons. The HCAP enables researchers to measure and understand dementia risk in ongoing longitudinal studies of aging around the world by using methods and content that are as similar as possible. NIA-funded Mobile Monitoring of Cognitive Change infrastructure projects are developing and testing tools that measure cognitive abilities using mobile devices that can be adopted in dementia clinical research studies.
The key accomplishments summary is current as of July 2022.
- PAR-15-356: Major Opportunities for Research in Epidemiology of Alzheimer’s Disease and Cognitive Resilience (R01)
- RFA-AG-15-015: Enhancing Cross-National Research within the Health and Retirement Study Family Studies (R01)
- RFA-AG-18-005: The Health and Retirement Study (U01)
- RFA-NS-17-012: Detecting Cognitive Impairment, Including Dementia, in Primary Care and Other Everyday Clinical Settings for the General Public and in Health Disparities Populations
- RFA-AG-19-016: High-Priority Behavioral and Social Research Networks in Alzheimer's Disease and Alzheimer's Disease Related Dementias
- PA-18-588: Assistive Technology for Persons with Alzheimer's Disease and Related Dementias and Their Caregivers
- PA-18-185: Development of Socially-Assistive Robots (SARs) to Engage Persons with Alzheimer's Disease (AD) and AD-Related Dementias
- NSF-18-541: Smart and Connected Health (SCH):Connecting Data, People and Systems
- RFA-AG-20-022: Aging, Driving and Early Detection of Dementia (R01 Clinical Trial Optional)
Research Programs and Resources
- Harmonized Cognitive Assessment Platform (HCAP)
- Health Retirement Study: Harmonized Cognitive Assessment Protocol
- Mexican Health and Aging Study
- Harmonized Diagnostic Assessment of Dementia (DAD) for Longitudinal Aging Study of India
- Harmonized Cognitive and Dementia Assessment in China
- English Longitudinal Study of Aging (ELSA)
- Survey of Health, Aging and Retirement in Europe (SHARE)
- High-Priority Behavioral and Social Research Networks in Alzheimer's Disease and Alzheimer's Disease Related Dementias
- Research Network for the Harmonized Cognitive Assessment Protocol (HCAP)
- 2015 AD Summit: 4B
- 2017 Dementia Care Summit: 2.5
- 2018 AD Summit: 6M
- 2020 Dementia Care Summit: 4.4, 4.6