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Biomarkers: Biomarkers for target engagement (Milestone 9.C)

In Progress

Timeline Start - End

2014 - 2024

Research Implementation Area


Initiate development of imaging and/or fluid biomarkers to demonstrate target engagement for 5 novel therapeutic targets for AD and AD-related dementias.

Success Criteria

Identification of 3 imaging and/or fluid biomarkers for which there is proof of engagement of novel therapeutic targets.

Summary of Key Accomplishments

NIA supports biomarker discovery by academic institutions and small biotech companies through targeted and non-targeted funding initiatives. Seven new imaging biomarkers (five PET ligands and two MRI-based markers) reflecting synaptic function, oxidative stress, and neuroinflammation are being developed and evaluated in animal models and in humans. In addition, 28 projects have been funded that support the discovery of novel blood-based biomarkers using various genomic technologies.

The key accomplishments summary is current as of March 2022. 

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