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Diagnosis, Assessment, and Disease Monitoring Milestones

9.A-9.W, 11.A-11.N

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37 Results

ID

Title

Status

Develop and validate translatable biomarkers for their use in preclinical and clinical drug development...

Status

In Progress

Accelerate the development of the next generation CNS imaging ligands and biofluid molecular signatures...

Status

In Progress

Initiate development of imaging and/or fluid biomarkers to demonstrate target engagement for 5 novel therapeutic targets for AD...

Status

In Progress

Incorporate imaging and/or fluid biomarkers into Phase 2 (proof of concept) drug trials to provide proof of mechanism and/or evidence of target engagement as trials...

Status

Achieved

Incorporate imaging and/or fluid biomarkers into Phase 3 (pivotal) drug trials to select subjects and/or provide evidence of target engagement...

Status

Achieved

Initiate studies to develop minimally invasive biomarkers for detection of cerebral amyloidosis, AD and AD-related dementias pathophysiology.

Status

Achieved

Initiate studies to link peripheral blood-based molecular signatures and central imaging and CSF biomarkers.

Status

Achieved

Launch research programs to develop and validate sensitive neuropsychological and behavioral assessment measures...

Status

Achieved

Develop and test methods for the standardization of immunoassays and mass-spectrometry/single reaction monitoring assay...

Status

Achieved

Longitudinal antemortem LBD characterization

Status

In Progress

Detect cognitive impairment when a patient or relative voices a concern to health care providers.

Status

In Progress

Improving differential diagnosis of symptomatic cognitive impairment.

Status

In Progress

Develop diagnostics/biomarkers in asymptomatic individuals.

Status

In Progress

Determining the value of screening for clinically relevant cognitive impairment in the absence of a cognitive complaint.

Status

To Be Initiated

Neuroimaging characterization of LBD

Status

In Progress

LBD biomarker development

Status

In Progress

Develop FTD biomarkers for diagnosis and disease progression.

Status

In Progress

Develop and validate longitudinally tracked noninvasive markers of key vascular processes related to cognitive and neurologic impairment.

Status

In Progress

Develop novel blood/CSF biomarkers or PET ligands for FTLD-tau, -TDP or -FUS during life

Status

In Progress

Biomarker and risk profiles for TDP-43

Status

In Progress

Support systematic evaluation of AT(N) research framework across multi-ethnic populations

Status

In Progress

Expand the AT(N) framework

Status

To Be Initiated

Develop diagnostic and prognostic algorithms for use in clinical trials and in clinical practice.

Status

In Progress

Develop research programs aimed at evaluating a variety of technologies for in-place monitoring of individuals at all stages of disease...

Status

Achieved

Continue to develop standard outcome measures to enable data comparisons across studies...

Status

In Progress

Embed wearable technologies as well as pervasive computing approaches in existing and new clinical research...

Status

In Progress

Support the development and commericialization of wearables that can increase rigor in measuring environmental exposures and intervention dosing...

Status

In Progress

Build end-to-end secure, high frequency data capture platforms to enable continuous monitoring of research participants...

Status

In Progress

Maintain an open-access national repository of evidence -based tools for cognitive assessment...

Status

In Progress

Launch programs on impact of diagnosis on individuals and families, to include individual response and social impacts.

Status

In Progress

Improve tools for assessment of risks, preclinical characteristics, and costs among health disparities populations by leveraging existing data/cohorts, designing targeted studies, and using psychometric analyses.

Status

In Progress

Increase utilization of culturally- and linguistically-appropriate assessment tools within ongoing and newly generated studies of AD/ADRD and vascular health intervention trials.

Status

In Progress

Increase training of health professionals to meet the demand for cognitive impairment and dementia diagnosis, care, and need for human-based research.

Status

In Progress

Characterize the clinical phenotype of progressive dementia associated with TBI

Status

In Progress

Intervention studies to investigate reversible causes of dementia.

Status

In Progress

TDP-43 in AD/ADRD: Differential diagnosis

Status

In Progress

Understanding the impact of COVID-19 on cognitive function

Status

In Progress

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