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Alzheimer's Disease and Related Dementias Research Implementation Milestone Database

This database is a web-based tool for tracking funding initiatives and activities developed by the NIH and other funding organizations supporting Alzheimer's Disease  and AD-Related Dementias (AD+ADRD) aimed at achieving the research milestones associated with the first goal of the National Plan to Address Alzheimer's: to treat and prevent Alzheimer's by 2025. The purpose of this new data resource is to facilitate strategic coordination and collaborations among funding organizations in order to maximize the public health impact of the collective investment in AD+ADRD research.

The milestones represent a research framework detailing specific steps and success criteria for the NIH and other stakeholders towards the development of effective treatments for AD+ ADRD. They were developed based on recommendations from the Strategic Research Planning Summits: NIH AD Research Summits 2012 and 2015 and the NIH ADRD Research Summits 2013 and 2016 put forward by over 200 leading academic and industry experts, innovators and public advocates. The milestones span the entire AD+ADRD research landscape including basic, translational, clinical and health services research and serve as the basis for the development of the NIH Alzheimer's Disease Bypass Budget.

The database can be searched based on research implementation areas and/or the Common Alzheimer's Disease Research Ontology (CADRO) categories. For each milestone, in addition to listing new funding initiative and programs, the database links to relevant projects funded by over 35 funding organizations, members of the International Alzheimer's Disease Research Portfolio (IADRP).

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Estimated Start Sort descending Research Implementation Area CADRO Category Title
2013 Public Private Partnerships G. Consortia and Public Private Partnerships 14.A: Convene an advisory meeting focused on facilitating public-private partnerships aimed at accelerating the development and test of effective therapies for AD treatment and prevention...
2013 Drug Development - Novel Targets C. Translational Research and Clinical Intervention 6.A: Establish a searchable, open access research database that contains all clinical, biomarker, and epidemiological data, and related genotypes and phenotypes from existing genetic studies…
2013 Drug Development - Novel Targets A. Molecular Pathogenesis and Physiology of Alzheimer's Disease 6.B: Establish a consortium of genetics and genomics experts to develop and execute a large scale sequencing project to analyze the genomes of a large number of well characterized individuals…
2013 Portfolio Analysis Tools and Methods F. Research Resources 15.A: Develop a common Alzheimer’s disease research ontology...
2014 Translational Tools, Infrastructure and Capabilities F. Research Resources 4.I: Create a National IRB.
2014 Biomarkers B. Diagnosis, Assessment and Disease Monitoring 9.B: Accelerate the development of the next generation CNS imaging ligands and biofluid molecular signatures...
2014 Biomarkers B. Diagnosis, Assessment and Disease Monitoring 9.C: Initiate development of imaging and/or fluid biomarkers to demonstrate target engagement for 5 novel therapeutic targets for AD...
2014 Public Private Partnerships G. Consortia and Public Private Partnerships 14.B: Convene meetings of the working groups for (i) Rapid Data Sharing and Analysis, (ii) Enabling Bidirectional Translation in AD drug development, (iii) Eliminating IP barriers for Target Validation...
2014 Recruitment and Citizen Engagement F. Research Resources 12.I: Establish a working group including clinical trial recruitment experts to dynamically evaluate and update the materials and information provided in the central resource.
2014 Drug Development - Novel Targets A. Molecular Pathogenesis and Physiology of Alzheimer's Disease 6.C: Identify, characterize, and complete early validation for at least 6 novel therapeutic targets for AD and AD-related dementias…
2014 Biomarkers B. Diagnosis, Assessment and Disease Monitoring 9.H: Launch research programs to develop and validate sensitive neuropsychological and behavioral assessment measures...
2014 Biomarkers B. Diagnosis, Assessment and Disease Monitoring 9.I: Develop and test methods for the standardization of immunoassays and mass-spectrometry/single reaction monitoring assay...
2014 Translational Tools, Infrastructure and Capabilities C. Translational Research and Clinical Intervention 4.G: Support quantitative systems pharmacology approaches that couple biological network and pathway analyses…
2014 Trial Design C. Translational Research and Clinical Intervention 10.B: Establish a working group to identify standard outcome measures necessary for data comparisons across secondary prevention trials...
2015 Trial Design C. Translational Research and Clinical Intervention 10.C: Initiate 3-4 clinical research studies using common standard outcome measures...
2015 Drug Development - Existing Targets C. Translational Research and Clinical Intervention 5.B: Initiate phase II (proof of concept) drug trials for agents against 3-6 currently known therapeutic targets…
2015 Research on Care and Caregiver Support E. Care, Support and Health Economics of Alzheimer's Disease 13.G: Leverage existing palliative care research networks to develop and advance interventions for palliative and hospice care of persons with advanced dementia and their families.
2015 Recruitment and Citizen Engagement F. Research Resources 12.H: Collaborate with research scientists to identify, evaluate and increase knowledge about best practices for recruitment and retention of research participants.
2015 Biomarkers B. Diagnosis, Assessment and Disease Monitoring 9.F: Initiate studies to develop minimally invasive biomarkers for detection of cerebral amyloidosis, AD and AD-related dementias pathophysiology.
2015 Recruitment and Citizen Engagement D. Epidemiology 12.J: Collaborate with external organizations to increase awareness of large-scale registries that encompass the spectrum of the disease ...
2016 Population Studies and Precision Medicine Research D. Epidemiology 1.A: Enable precision medicine research by supporting deep and longitudinal, molecular endophenotyping of existing and new, at-risk cohorts as well cohorts and/or individuals…
2016 Recruitment and Citizen Engagement C. Translational Research and Clinical Intervention 12.C: Provide supplemental support for clinical research on AD and related dementias to overcome the major logistical barriers to participation...
2016 Health Disparities: Monitoring Changes H. AD-related 19.B.3 Develop a system to monitor the magnitude and trends in health disparities in incidence of AD/ADRD.
2016 Data Sharing and Reproducibility F. Research Resources 3.B: Provide support to establish/improve the interoperability among relevant biomedical data repositories.…
2016 Population Studies and Precision Medicine Research D. Epidemiology 1.B: Quantify the exposome in existing and new AD cohorts to gain a more precise measure of environmental exposure factors…