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Longitudinal Studies Section

The Longitudinal Studies Section of the Translational Gerontology Branch of the Intramural Program of the National Institute on Aging focuses on mechanisms underlying heterogeneity in human health and function with aging, including molecular, cellular, physiologic and behavioral factors. In addition to our longitudinal studies of aging, including BLSA and Gestalt, we carry out smaller human studies of mechanisms and collaborate with other laboratories to pursue translational aging research across species.

Portfolio/Research Areas

  • Normal human aging across the adult lifespan, including molecular, cellular, physiologic and behavioral factors.
  • Special issues in exceptionally healthy aging
  • The role of the biological "hallmarks of aging" in human aging
  • The roles and interactions among body composition, energetics, homeostasis and neuroplasticity in contributing to age- related health and function.
  • Normal human aging across the adult lifespan, including molecular, cellular, physiologic and behavioral factors.
  • Special issues in exceptionally healthy aging
  • The role of the biological "hallmarks of aging" in human aging
  • The roles and interactions among body composition, energetics, homeostasis and neuroplasticity in contributing to age- related health and function.

Findings and Publications

Simonsick EM, Glynn NW, Jerome GJ, Shardell M, Schrack JA, Ferrucci L. Fatigued, but not frail: Perceived fatigability as a marker of impending decline in mobility-intact older adults. J Am Geriatr Soc 2016;64:1287-1292. PMID: 27253228

Fabbri E, An Y, Zoli M, Tanaka T, Simonsick EM, Kitner-Triolo MH, Studenski SA, Resnick SM, Ferrucci L. Association between accelerated multimorbidity and age-related cognitive decline in older Baltimore Longitudinal Study of Aging participants without dementia. J Am Geriatr Soc. 2016 May;64(5):965-72.

β-Amyloid Burden Predicts Lower Extremity Performance Decline in Cognitively Unimpaired Older Adults.J Gerontol A Biol Sci Med Sci. 2017 May 1;72(5):716-723.

Fabbri E, Chia CW, Spencer RG, Fishbein KW, Reiter DA, Cameron D, Zane AC, Moore ZA, Gonzalez-Freire M, Zoli M, Studenski SA, Kalyani RR, Egan JM, Ferrucci L. Insulin Resistance Is Associated With Reduced Mitochondrial Oxidative Capacity Measured by 31P-Magnetic Resonance Spectroscopy in Participants Without Diabetes From the Baltimore Longitudinal Study of Aging. Diabetes. 2017 Jan;66(1):170-176. PMID:27737951

Schrack JA, Knuth ND, Simonsick EM, Ferrucci L. "IDEAL" aging is associated with lower resting metabolic rate: the Baltimore Longitudinal Study of Aging. J Am Geriatr Soc. 2014 Apr;62(4):667-72. PMID:24635835