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IRP Core: Nonhuman Primate Core

Julie Mattison, Ph.D., Chief

The NHP Core of the Translational Gerontology Branch, NIA, IRP, was established in 2013 to support the experimental goals of intramural investigators and their collaborators. We offer research services supporting multi-disciplinary translational aging projects with in vivo and in vitro projects for intramural and extramural investigators. We maintain a colony of rhesus monkeys, ranging in age from 4 to 32 years, that are available for in vivo projects. When a collaborative project is initiated, the NHP Core works collectively with investigators to develop experimental methods aimed at answering their research question. Following methods development, we compose study amendments and work with the NIA ACUC through the submission and approval process. Once approved, Core personnel conduct all study procedures, and collect, process, and organize data and physiological samples until they are dispatched to the investigator for analyses. In addition, our core facility maintains an extensive collection of NHP tissue samples available for projects or validation studies.

The Core also continues to support the nearly three decades long calorie restriction in rhesus monkeys study. In addition to longevity, overall health and functional measures are regularly documented. We are collecting measures of metabolism, immune function, gene changes, sensory systems, pulse wave velocity, body composition, activity, motor function, learning and memory.

Portfolio/Research Areas

  • Nonhuman primate aging
  • Translational models
  • Calorie restriction
  • Nutrition interventions
  • Immune function
  • Learning and memory
  • Pharmacokinetic evaluations

Findings and Publications

Mattison JA, Colman RJ, Beasley TM, Allison DB, Kemnitz JW, Roth GS, Ingram DK, Weindruch R, de Cabo R, Anderson RM. Caloric restriction improves health and survival of rhesus monkeys. Nat Commun. 2017 Jan 17;8:14063. PubMed PMID: 28094793; PubMed Central PMCID: PMC5247583.

Mattison JA, Roth GS, Beasley TM, Tilmont EM, Handy AM, Herbert RL, Longo DL, Allison DB, Young JE, Bryant M, Barnard D, Ward WF, Qi W, Ingram DK, de Cabo R. Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature. 2012 Sep 13;489(7415):318-21. PubMed PMID: 22932268; PubMed Central PMCID: PMC3832985.

Moon HY, Becke A, Berron D, Becker B, Sah N, Benoni G, Janke E, Lubejko ST, Greig NH, Mattison JA, Duzel E, van Praag H. Running-induced systemic cathepsin B secretion is associated with memory function. Cell Metab. 2016 Aug 9;24(2):332-40. PubMed PMID: 27345423.

Mera P, Laue K, Ferron M, Confavreux C, Wei J, Galán-Díez M, Lacampagne A, Mitchell SJ, Mattison JA, Chen Y, Bacchetta J, Szulc P, Kitsis RN, de Cabo R, Friedman RA, Torsitano C, McGraw TE, Puchowicz M, Kurland I, Karsenty G. Osteocalcin signaling in myofibers Is necessary and sufficient for optimum adaptation to exercise. Cell Metab. 2017 Jan 10;25(1):218. PubMed PMID: 28076763.

Mattison JA, Wang M, Bernier M, Zhang J, Park SS, Maudsley S, An SS, Santhanam L, Martin B, Faulkner S, Morrell C, Baur JA, Peshkin L, Sosnowska D, Csiszar A, Herbert RL, Tilmont EM, Ungvari Z, Pearson KJ, Lakatta EG, de Cabo R. Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates. Cell Metab. 2014 Jul 1;20(1):183-90. PubMed PMID: 24882067; PubMed Central PMCID: PMC4254394.