Laboratory of Molecular Gerontology
Vilhelm A. Bohr, MD PhD, Chief
The laboratory of Molecular Gerontology (LMG) works on genomic instability and how that leads to aging. We study DNA maintenance and repair using biochemical approaches, cell biology and in animal models. These include nematode worms and mouse models mimicking human diseases of accelerated aging. We also study mitochondria and bioenergetics as it relates to disease and aging. We are developing interventions that slow down the aging process and counter neurodegeneration.
- DNA repair
- Telomere maintenance
- Base excision DNA repair
- Helicase function
NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair. Fang EF, Kassahun H, Croteau DL, Scheibye-Knudsen M, Marosi K, Lu H, Shamanna RA, Kalyanasundaram S, Bollineni RC, Wilson MA, Iser WB, Wollman BN, Morevati M, Li J, Kerr JS, Lu Q, Waltz TB, Tian J, Sinclair DA, Mattson MP, Nilsen H, Bohr VA. Cell Metab. 2016 Oct 11;24(4):566-581. PMID: 27732836
Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA. Scheibye-Knudsen M, Tseng A, Borch Jensen M, Scheibye-Alsing K, Fang EF, Iyama T, Bharti SK, Marosi K, Froetscher L, Kassahun H, Eckley DM, Maul RW, Bastian P, De S, Ghosh S, Nilsen H, Goldberg IG, Mattson MP, Wilson DM 3rd, Brosh RM Jr, Gorospe M, Bohr VA. Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12502-12507.
Biochemical Characterization of the Human Mitochondrial Replicative Twinkle Helicase: SUBSTRATE SPECIFICITY, DNA BRANCH MIGRATION, AND ABILITY TO OVERCOME BLOCKADES TO DNA UNWINDING.
Khan I, Crouch JD, Bharti SK, Sommers JA, Carney SM, Yakubovskaya E, Garcia-Diaz M, Trakselis MA, Brosh RM Jr. J Biol Chem. 2016 Jul 1. PMID: 27226550
Wan B, Yin J, Horvath K, Sarkar S, Chen Y, Wu J, Wan K, Lu J, Gu P, Yu EY, Lue NF, Chang S, Lei M.* Liu Y,* SLX4 Assembles a Telomere Maintenance Toolkit by Bridging Multiple Endonucleases with Telomeres.
Cell Reports. 4:861-869, 2013. PMID:24012755