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Immunoregulation Section

Arya Biragyn, Ph.D., Chief

The focus of Dr. Biragyn’s research is to understand the “immunological paradox of aging”; that is, why cancer incidence is enhanced but cancers often grow more slowly in older people, and why autoimmunity is more prevalent in the elderly but older people have poor vaccine responses. He hypothesizes that this may be a reflection of disbalance between the regulatory immune system and the accumulation of potentially pathogenic immune cells in aging. His goal is to gain insights in aging immune dysregulation and cancer immunoregulation to develop a simple but potent immunotherapeutics tailored for elderly.

Portfolio/Research Areas

  • Regulatory Immune cells in cancer escape
  • Aging immune dysregulation
  • Development of immunotherapeutic strategies

Findings and Publications

Biragyn A, Aliseychik M, Rogaev E. Potential importance of B cells in aging and aging-associated neurodegenerative diseases. Semin Immunopathol. 2017 Jan 12. doi: 10.1007/s00281-016-0615-8. [Epub ahead of print] Review.
PubMed PMID: 28083646.

Gordy JT, Luo K, Zhang H, Biragyn A, Markham RB. Fusion of the dendritic cell-targeting chemokine MIP3α to melanoma antigen Gp100 in a therapeutic DNA vaccine significantly enhances immunogenicity and survival in a mouse melanoma model. J Immunother Cancer. 2016 Dec 20;4:96. doi: 10.1186/s40425-016-0189-y.
eCollection 2016 Dec 20. PubMed PMID: 28018602; PubMed Central PMCID: PMC5168589.

Lee-Chang C, Bodogai M, Moritoh K, Chen X, Wersto R, Sen R, Young HA, Croft M,Ferrucci L, Biragyn A. Aging converts innate B1a cells into potent CD8+ T Cell inducers. J Immunol. 2016 Apr 15;196(8):3385-97.doi:10.4049/jimmunol.1502034.Epub 2016 Mar 16. PubMed PMID: 26983789; PubMed Central PMCID: PMC4821757.

Hiyoshi M, Okuma K, Tateyama S, Takizawa K, Saito M, Kuramitsu M, Araki K, Morishita K, Okada S, Yamamoto N, Biragyn A, Yamaguchi K, Hamaguchi I. Furin-dependent CCL17-fused
recombinant toxin controls HTLV-1 infection by targeting and eliminating infected CCR4-expressing cells in vitro and in vivo
. Retrovirology. 2015 Aug 20;12:73. doi: 10.1186/s12977-015-0199-8.
PubMed PMID: 26289727; PubMed Central PMCID: PMC4545545.

Bodogai M, Moritoh K, Lee-Chang C, Hollander CM, Sherman-Baust CA, Wersto RP, Araki Y, Miyoshi I, Yang L, Trinchieri G, Biragyn A. Immunosuppressive and
prometastatic functions of myeloid-derived suppressive cells rely upon education from tumor-associated B cells
. Cancer Res. 2015 Sep 1;75(17):3456-65. doi:10.1158/0008-5472.CAN-14-3077. Epub 2015 Jul 16. PubMed PMID: 26183924; PubMedCentral PMCID:PMC4558269.