Complex LCR Detector
Description and Data Source
The program LCRSimulationAnalysis was created by Alexander Maltsev at the Laboratory of Cardiovascular Science at the National Institute of Aging, National Institutes of Health. The program detects and analyses complex Local Ca Releases in numerical simulations of intracellular Ca dynamics in cardiac pacemaker cells (sinoatrial node cells) using Stern et al. model published in 2014 in Journal of General Physiology 2014 May;143(5):577-604.
Link to PubMed Article PMC 4003189
Manuscript
The C++ code was developed and described in detail as a part of a research paper published August 8, 2017 in PLoS Computational Biology:
Alexander V. Maltsev, Victor A. Maltsev, Michael D. Stern. Stabilization of diastolic calcium signal via calcium pump regulation of complex local calcium releases and transient decay in a computational model of cardiac pacemaker cell with individual release channels. PLoS Comput Biol 13(8): e1005675.
Link to PubMed Article PMC 5562330
Data Example and C++ code
Please send your request for the most recent code and data example to Victor Maltsev (maltsevvi@mail.nih.gov) or Michael Stern (SternMi@mail.nih.gov).