Immune Cells and Inflammation Section
Description of Research Program
Research in our laboratory focuses on the effects of chronic systemic inflammation in the manifestation of Parkinson’s and Alzheimer’s diseases. In particular, we are interested in understanding the role of immune cells in the brain, the gut and in the traditional peripheral compartments in association with the gut-microbiota in the development of age-related chronic systemic inflammation, cellular senescence and neurodegeneration.
Findings and Selected Publications:
Singh, A., Verma, A., Sallin, M. A., Lang, F., Sen, R. and Sen, J. M. Noncoding variations in Cyp24a1 gene are associated with Klotho-mediated aging phenotypes in different strains of mice. Aging Cell, 2019.
Kishimoto Y, Zhu W, Hosoda W, Sen J.M., Mattson MP. Chronic Mild Gut Inflammation Accelerates Brain Neuropathology and Motor Dysfunction in α-Synuclein Mutant Mice. Neuromolecular Medicine. 2019.
Zhang P, Kishimoto Y, Grammatikakis I, Gottimukkala K, Cutler RG, Zhang S, Abdelmohsen K, Bohr VA, Misra Sen J, Gorospe, M, Mattson, MP. Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer's disease model. Nature Neuroscience. 2019.
Zhu, W. S., Naler, L., Maul, R. W., Sallin, M. A. and Sen, J. M. Immune system development and age-related maintenance in Klotho-hypomorphic mice. Aging, 11:5246-57, 2019.
Patta, I., Madhok,A., Khare, S., Gottimukkala, K. P., Verma,A., Giri, S., Dandewad, V., Seshadri, V., Girdhari Lal, G., J Misra-Sen, J. and Galande, S. Dynamic regulation of chromatin organizer SATB1 via TCR-induced alternative promoter switch during T-cell development. Nucleic Acids Research, 48:11 5873, 2020.
Iba, M., Kim, C., Sallin, M., Kwon, S., Verma, A., Overk, C., Rissman, R. A., Sen, R., Misra Sen, J. and Masliah, E. Neuroinflammation is associated with infiltration of T cells in Lewy body disease and α-synuclein transgenic models. Journal of Neuroinflammation, 17:214, 2020.
Shawn P. Fahl, S. P., Contreras, A. V.,Verma, A., Xiang Qiu, X., Harly, C., Radtke, F., Zuniga-Pflucker, J. C., Murre, C., Xue, H-H., Misra Sen, J. and Wiest. D. L. The E protein-TCF1 axis controls gd T cell development and effector fate. Cell Reports 34, 108716, 2021.