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Proteome-based blood biomarkers of brain amyloid deposition during aging.

Proteome-based blood biomarkers of brain amyloid deposition during aging. In this study, we combined proteomic analysis of plasma with 11C-PiB PET imaging to identify plasma proteins predictive of brain amyloid deposition in non-demented older individuals. It was striking that in this unbiased study (i.e. without any a priori assumptions about the identity or nature of candidate biomarkers), the strongest signal associated with brain amyloid burden was from apolipoprotein-E (apoE).

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