Plasma clusterin concentration
Plasma clusterin concentration is related to severity, pathology and progression in AD. In this study, we combined proteomic analysis of plasma with distinct endophenotypes of AD such as hippocampal volume derived by MRI, rate of clinical progression and brain amyloid deposition to identify clusterin (also known as apolipoprotein-J/apoJ) as a biologically relevant blood biomarker of AD.
Fig 1. Schematic study design combining multi-modal neuroimaging with mass spectrometry-based proteomic analysis of plasma for discovery of biologically relevant biomarkers of AD