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Insulin resistance (IR) and its relationship to AD pathology and brain function.

Insulin resistance (IR) and its relationship to AD pathology and brain function.  We showed that insulin resistance (IR) is not related to the extent of AD pathology in non-demented individuals and that midlife IR is associated with longitudinal changes in brain function during aging.

Figure 3 - Insulin resistance (IR) and its relationship to AD pathology and brain function.

Fig-3. Differences in longitudinal change in regional cerebral blood flow between IGT and NGT groups. Blue areas indicate significantly greater longitudinal decreases in regional cerebral blood flow in the IGT group; yellow areas, greater longitudinal increases in regional cerebral blood flow in the IGT group. Abbreviations: IGT, impaired glucose tolerance; L, left; NGT, normal glucose tolerance; R, right.

 

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