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Brain Aging and Behavior Section

Susan Resnick, Ph.D, Chief

The Brain Aging and Behavior Section (BABS) studies cognitive and brain aging in health and disease. Section investigators conduct longitudinal cognitive and neuroimaging studies (1) to characterize the magnitude, rate, and regional pattern of age changes in brain structure and function in healthy aging; (2) to investigate accelerated changes in brain structure and function that may be early markers of cognitive impairment and Alzheimer’s disease; (3) to track trajectories of biomarker changes that may provide insights into the pathophysiology of Alzheimer’s disease during its preclinical (asymptomatic) stage; (4) to investigate factors that modify brain-behavior associations in aging, including factors that promote cognitive and affective resilience as well as those that increase risk for cognitive impairment and Alzheimer’s disease; (5) to examine effects of sex, hormones, and other neurobiologic and cultural influences on individual differences in behavior, and the links between behavior and physical health across the lifespan.

Postdoctoral Fellowship Positions Available:  Contact Dr. Susan Resnick at susan.resnick@nih.gov.

List of Portfolio/Research Areas

  • Cognitive and brain aging;
  • Neuroimaging biomarkers of cognitive decline, impairment and resilience;
  • Predictors and modifiers of cognitive and brain changes, including genetics, sex steroid hormones, and co-morbidities
  • Biologic underpinnings of “cognitive resilience” in carriers of the Apolipoprotein E (APOE) e4 risk allele for Alzheimer’s disease

Selected Publications 2016-2020

2016

Bilgel M, Prince JL, Wong DF, Resnick SM, Jedynak BM. A multivariate nonlinear mixed effects model for longitudinal image analysis: Application to amyloid imaging.  Neuroimage. 2016;134:658-670. PMCID: PMC4912927

Gonzalez CE, Venkatraman VK, An Y, Landman BA, Davatzikos C, Ratnam Bandaru VV, Haughey NJ, Ferrucci L, Mielke MM, Resnick SM.  Peripheral sphingolipids are associated with variation in white matter microstructure in older adults.  Neurobiol Aging 2016;43:156-63. PMCID: PMC4894643

Goh JO, Su YS, Tang YJ, McCarrey AC, Tereshchenko A, Elkins W, Resnick SM.  Frontal, Striatal, and Medial Temporal Sensitivity to Value Distinguishes Risk-Taking from Risk-Aversive Older Adults during Decision Making.  J Neurosci. 2016;36(49):12498-12509.  PMCID: PMC5148232

Driscoll I, Gaussoin SA, Wassertheil-Smoller S, Limacher M, Casanova R, Yaffe K, Resnick SM, Espeland MA.  Obesity and Structural Brain Integrity in Older Women: The Women's Health Initiative Magnetic Resonance Imaging Study.  J Gerontol A Biol Sci Med Sci. 2016;71:1216-1222. PMCID: PMC4978361

Spira AP, Gonzalez CE, Venkatraman VK, Wu MN, Pacheco J, Simonsick EM, Ferrucci L, Resnick SM.  Sleep Duration and Subsequent Cortical Thinning in Cognitively Normal Older Adults.  Sleep 2016;39(5):1121-8. PMCID: PMC4835311

2017

Resnick SM*, Matsumoto AMI, Stephens-Shields AJ, Ellenberg SS, Gill TM, Shumaker SA, Pleasants DD, Barrett-Connor E, Bhasin S, Cauley JA, Cella D, Crandall JP, Cunningham GR, Ensrud KE, Farrar JT, Lewis CE, Molitch ME, Pahor M, Swerdloff RS, Cifelli D, Anton S, Basaria S, Diem SJ, Wang C, Hou X, Snyder PJ. Testosterone Treatment and Cognitive Function in Older Men with Low Testosterone and Age-Associated Memory Impairment. JAMA. 2017;317(7):717-727. PMCID: PMC5433758. *joint first authors

Terracciano A, An Y, Sutin AR, Thambisetty M, Resnick SM. Personality Change in the Preclinical Phase of Alzheimer Disease. JAMA Psychiatry. 2017;74(12):1259-1265.  PMCID: PMC5710607

Beason-Held LL, Hohman TJ, Venkatraman V, An Y, Resnick SM. Brain network changes and memory decline in aging. Brain Imaging Behav. 2017;11(3):859-873. PMCID: PMC5164979

Tian Q, Resnick SM, Bilgel M, Wong DF, Ferrucci L, Studenski SA. β-Amyloid Burden Predicts Lower Extremity Performance Decline in Cognitively Unimpaired Older Adults. J Gerontol A Biol Sci Med Sci. 2017;72(5):716-723. PMCID: PMC6075426

Ennis GE, An Y, Resnick SM, Ferrucci L, O'Brien RJ, Moffat SD.  Long-term cortisol measures predict Alzheimer disease risk.  Neurology 2017;88(4):371-378.  PMCID: PMC5272965

Mielke MM, Haughey NJ, Han D, An Y, Bandaru VV, Lyketsos CG, Ferrucci L, Resnick SM.  The Association Between Plasma Ceramides and Sphingomyelins and Risk of Alzheimer's Disease Differs by Sex and APOE in the Baltimore Longitudinal Study of Aging.  J Alzheimers Dis. 2017;60(3):819-828. PMCID: PMC5493514.

Gross AL, Hassenstab JJ, Johnson SC, Clark LR, Resnick SM, Kitner-Triolo M, Masters CL, Maruff P, Morris JC, Soldan A, Pettigrew C, Albert MS. A classification algorithm for predicting progression from normal cognition to mild cognitive impairment across five cohorts: The preclinical AD consortium.  Alzheimers Dement (Amst). 2017; 8:147-155. PMCID: PMC5476965.

Bilgel M, Koscik RL, An Y, Prince JL, Resnick SM, Johnson SC, Jedynak BM.  Temporal Order of Alzheimer's Disease-Related Cognitive Marker Changes in BLSA and WRAP Longitudinal Studies. J Alzheimers Dis. 2017;59(4):1335-1347. PMCID: PMC5682938

Spira AP, An Y, Peng Y, Wu MN, Simonsick EM, Ferrucci L, Resnick SM. APOE Genotype and Nonrespiratory Sleep Parameters in Cognitively Intact Older Adults. Sleep. 2017;40(8). PMCID: PMC5804995

Wolf C, An Y, Tanaka T, Bilgel M, Gonzalez C, Kitner Triolo M, Resnick S.  Cross-Sectional and Longitudinal Effects of CREB1 Genotypes on Individual Differences in Memory and Executive Function: Findings from the BLSA.  Front Aging Neurosci. 2017; 9:142. PMCID: PMC5432543

Erus G, Doshi J, An Y, Verganelakis D, Resnick SM, Davatzikos C. Longitudinally and inter-site consistent multi-atlas based parcellation of brain anatomy using harmonized atlases. Neuroimage. 2017; 166:71-78. PMCID: PMC5748021

2018

Bilgel M, An Y, Helphrey J, Elkins W, Gomez G, Wong DF, Davatzikos C, Ferrucci L, Resnick SM.  Effects of amyloid pathology and neurodegeneration on cognitive change in cognitively normal adults.  Brain. 2018;141(8):2475-2485.  PMCID: PMC6061788

Gomez G, Beason-Held LL, Bilgel M, An Y, Wong DF, Studenski S, Ferrucci L, Resnick SM. Metabolic Syndrome and Amyloid Accumulation in the Aging Brain. J Alzheimers Dis. 2018;65(2):629-639. PMCID: PMC6176485.

Williams OA, An Y, Beason-Held L, Huo Y, Ferrucci L, Landman BA, Resnick SM. Vascular burden and APOE ε4 are associated with white matter microstructural decline in cognitively normal older adults. Neuroimage. 2018;188:572-583. PMCID: PMC30557663

Warren KN, Beason-Held LL, Carlson O, Egan JM, An Y, Doshi J, Davatzikos C, Ferrucci L, Resnick SM. Elevated Markers of Inflammation Are Associated with Longitudinal Changes in Brain Function in Older Adults.  J Gerontol A Biol Sci Med Sci. 2018;73(6):770-778. PMCID: PMC5946946

Tian Q, Bair WN, Resnick SM, Bilgel M, Wong DF, Studenski SA.  β-amyloid deposition is associated with gait variability in usual aging. Gait Posture. 2018; 61:346-352. PMCID: PMC5866772

Spira AP, An Y, Wu MN, Owusu JT, Simonsick EM, Bilgel M, Ferrucci L, Wong DF, Resnick SM. Excessive daytime sleepiness and napping in cognitively normal adults: associations with subsequent amyloid deposition measured by PiB PET. Sleep. 2018;41(12). PMCID: PMC6289234.

 

2019

Armstrong NM, An Y, Beason-Held L, Doshi J, Erus G, Ferrucci L, Davatzikos C, Resnick SM. Predictors of neurodegeneration differ between cognitively normal and subsequently impaired older adults. Neurobiol Aging. 2019;75:178-186. PMCID:6394867

Armstrong NM, An Y, Beason-Held L, Doshi J, Erus G, Ferrucci L, Davatzikos C, Resnick SM. Sex differences in brain aging and predictors of neurodegeneration in cognitively healthy older adults. Neurobiol Aging. 2019; 81:146-156. PMC pending.

Williams OA, An Y, Armstrong NM, Shafer AT, Helphrey J, Kitner-Triolo M, Ferrucci L, Resnick SM. Apolipoprotein E ε4 allele effects on longitudinal cognitive trajectories are sex and age dependent. Alzheimers Dement. 2019;15(12):1558-1567. PMC: Pending

Ziontz J, Bilgel M, Shafer AT, Moghekar A, Elkins W, Helphrey J, Gomez G, June D, McDonald MA, Dannals RF, Azad BB, Ferrucci L, Wong DF, Resnick SM. Tau pathology in cognitively normal older adults. Alzheimers Dement (Amst). 2019;11:637-645. PMCID: PMC6732758.

Bell WR, An Y, Kageyama Y, English C, Rudow GL, Pletnikova O, Thambisetty M, O'Brien R, Moghekar AR, Albert MS, Rabins PV, Resnick SM, Troncoso JC. Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy (PART) and Alzheimer's disease. Alzheimers Dement. 2019;15(1):8-16. PMCID: PMC6542566

Hayden KM, Gaussoin SA, Hunter JC, Manson JE, Sachs BC, Shadyab AH, Tindle HA, Mossavar-Rahmani Y, Mozhui K, Snively BM, Rapp SR, Resnick SM. Cognitive resilience among APOE ε4 carriers in the oldest old. Int J Geriatr Psychiatry.  2019;34(12):1833-1844. PMCID: PMC7143252.

Driscoll I, Snively BM, Espeland MA, Shumaker SA, Rapp SR, Goveas JS, Casanova RL, Wactawski-Wende J, Manson JE, Rossom R, Brooks J, Hernandez DG, Singleton AB, Resnick SM. A candidate gene study of risk for dementia in older, postmenopausal women: Results from the Women's Health Initiative Memory Study. Int J Geriatr Psychiatry 2019;34(5):692-699. PMCID: PMC6608707.

Armstrong NM, Huang CW, Williams OA, Bilgel M, An Y, Doshi J, Erus G, Davatzikos C, Wong DF, Ferrucci L, Resnick SM. Sex differences in the association between amyloid and longitudinal brain volume change in cognitively normal older adults. Neuroimage Clin. 2019; 22:101769. PMCID: PMC6444285.

Armstrong NM, An Y, Doshi J, Erus G, Ferrucci L, Davatzikos C, Deal JA, Lin FR, Resnick SM. Association of Midlife Hearing Impairment with Late-Life Temporal Lobe Volume Loss. JAMA Otolaryngol Head Neck Surg. 2019 Jul 3. PMCID: PMC6613307.

Grober E, An Y, Lipton RB, Kawas C, Resnick SM. Timing of onset and rate of decline in learning and retention in the pre-dementia phase of Alzheimer's disease. J Int Neuropsychol Soc. 2019;25(7):699-705. PMCID: PMC6747692.

 

2020

Williams OA, An Y, Armstrong NM, Kitner-Triolo M, Ferrucci L, Resnick SM. Profiles of Cognitive Change in Preclinical and Prodromal Alzheimer's Disease Using Change-Point Analysis. J Alzheimers Dis. 2020;75(4):1169-1180. PMC pending.

Armstrong NM, An Y, Shin JJ, Williams OA, Doshi J, Erus G, Davatzikos C, Ferrucci L, Beason-Held LL, Resnick SM.  Associations between cognitive and brain volume changes in cognitively normal older adults.  Neuroimage, in press.  PMC pending.

Bilgel M, Beason-Held L, An Y, Zhou Y, Wong DF, Resnick SM. Longitudinal evaluation of surrogates of regional cerebral blood flow computed from dynamic amyloid PET imaging. J Cereb Blood Flow Metab. 2020;40(2):288-297. PMCID: PMC7370613

Han S, An Y, Carass A, Prince JL, Resnick SM. Longitudinal Analysis of Regional Cerebellum Volumes During Normal Aging. Neuroimage. 2020 Jun 24:117062. doi: 10.1016/j.neuroimage.2020.117062. PMC pending.

Beason-Held LL, Shafer AT, Goh JO, Landman BA, Davatzikos C, Viscomi B, Ash J, Kitner-Triolo M, Ferrucci L, Resnick SM. Hippocampal activation and connectivity in the aging brain. Brain Imaging Behav. 2020 Apr 20. doi:10.1007/s11682-020-00279-6. PMID: 32314198. PMC pending.

Armstrong NM, Dumitrescu L, Huang CW, An Y, Tanaka T, Hernandez D, Doshi J, Erus G, Davatzikos C, Ferrucci L, Resnick SM, Hohman TJ. Association of hippocampal volume polygenic predictor score with baseline and change in brain volumes and cognition among cognitively healthy older adults. Neurobiol Aging. 2020 May 21;94:81-88. PMC pending.

Koychev I, Vaci N, Bilgel M, An Y, Muniz GT, Wong DF, Gallacher J, Mogekhar A, Albert M, Resnick SM. Prediction of rapid amyloid and phospotylated-Tau accumulation in cognitively healthy individuals. Alzheimers Dement (Amst). 2020;12(1):e12019. PMC7086102.

Tian Q, Resnick SM, Mielke MM, Yaffe K, Launer LJ, Jonsson PV, Grande G, Welmer AK, Laukka EJ, Bandinelli S, Cherubini A, Rosano C, Kritchevsky SB, Simonsick EM, Studenski SA, Ferrucci L.  Association of dual decline in memory and gait speed with risk for dementia among adults older than 60 years: A multicohort individual-level meta-analysis.  JAMA Netw Open. 2020;3(2):e1921636.  PMCID: PMC7043189

Kuo PL, Schrack JA, Shardell MD, Levine M, Moore AZ, An Y, Elango P, Karikkineth A, Tanaka T, de Cabo R, Zukley LM, AlGhatrif M, Chia CW, Simonsick EM, Egan JM, Resnick SM, Ferrucci L. A roadmap to build a phenotypic metric of ageing: insights from the Baltimore Longitudinal Study of Aging. J Intern Med. 2020;287(4):373-394. PMC pending.