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Brain Aging and Behavior Section

Susan Resnick, Ph.D, Chief

The Brain Aging and Behavior section studies cognitive and brain aging in health and disease. Section investigators conduct longitudinal cognitive and neuroimaging studies (1) to characterize the magnitude, rate, and regional pattern of age changes in brain structure and function in healthy aging; (2) to investigate accelerated changes in brain structure and function that may be early markers of cognitive impairment and Alzheimer’s disease; (3) to track trajectories of biomarker changes that may provide insights into the pathophysiology of Alzheimer’s disease during its preclinical (asymptomatic) stage; (4) to investigate factors that modify brain-behavior associations in aging, including factors that promote cognitive and affective resilience as well as those that increase risk for cognitive impairment and Alzheimer’s disease; (5) to examine genetic, hormonal, and other neurobiological and cultural influences on individual differences in behavior, and the links between behavior and physical health across the lifespan.

List of Portfolio/Research Areas

  • Cognitive and brain aging;
  • Neuroimaging biomarkers of cognitive decline, impairment and resilience;
  • Predictors and modifiers of cognitive and brain changes, including genetics, sex steroid hormones, and co-morbidities

Findings and Publications

McCarrey AC, An Y, Kitner-Triolo MH, Ferrucci L, Resnick SM. Sex differences in cognitive trajectories in clinically normal older adults. Psychol Aging. 2016 Mar;31(2):166-75.

Bilgel M, An Y, Zhou Y, Wong DF, Prince JL, Ferrucci L, Resnick SM. Individual estimates of age at detectable amyloid onset for risk factor assessment. Alzheimers Dement. 2016 Apr;12(4):373-9.

Goh JO, Su YS, Tang YJ, McCarrey AC, Tereshchenko A, Elkins W, Resnick SM. Frontal, Striatal, and Medial Temporal Sensitivity to Value Distinguishes Risk-Taking from Risk-Aversive Older Adults during Decision Making. J Neurosci. 2016 Dec 7;36(49):12498-12509.

Ennis GE, An Y, Resnick SM, Ferrucci L, O'Brien RJ, Moffat SD. Long-term cortisol measures predict Alzheimer disease risk. Neurology 2017 Jan 24;88(4):371-378.

Resnick SM, Matsumoto AM, Stephens-Shields AJ, Ellenberg SS, Gill TM, Shumaker SA, Pleasants DD, Barrett-Connor E, Bhasin S, Cauley JA, Cella D, Crandall JP, Cunningham GR, Ensrud KE, Farrar JT, Lewis CE, Molitch ME, Pahor M, Swerdloff RS, Cifelli D, Anton S, Basaria S, Diem SJ, Wang C, Hou X, Snyder PJ.Testosterone Treatment and Cognitive Function in Older Men With Low Testosterone and Age-Associated Memory Impairment.JAMA. 2017 Feb 21;317(7):717-727.