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Laboratory of Behavioral Neuroscience

Susan Resnick, PhD, Chief

The fundamental scientific paradigm guiding research in the Laboratory of Behavioral Neuroscience (LBN) is the study of individual differences and age-related changes in cognition, personality, brain structure and function, and their influences on age-related changes.

The Laboratory of Behavioral Neuroscience

  1. Conducts basic and clinical research on individual differences in cognition, personality, and affect,
  2. Investigates the neural contributions to these individual differences,
  3. Investigates the influence of age on these traits and states and their reciprocal influence on cognitive and mental health, well-being, and adaptation,
  4. Examines predictors and modifiers of age-related neurodegenerative diseases and age-associated changes in behavior, predispositions, and brain-behavior associations,
  5. Identifies early markers of Alzheimer’s disease and cognitive decline, and examines factors that promote the maintenance of cognitive health.

Laboratory investigators employ a variety of methods, including experimental, longitudinal, epidemiological, neuroimaging, biomarker, neuropathological, and genetic methods in the analyses of behavioral, psychological, and biological aspects of aging.

List of Portfolio/Research Areas

  • Cognitive and brain aging;
  • Neuroimaging biomarkers of cognitive decline, impairment and resilience;
  • Blood-based biomarkers of cognitive impairment and Alzheimer's Disease using proteomic and metabolomic methods;
  • Molecular, cellular, anatomic and imaging approaches in animal models of cognitive aging;
  • Non-cholinergic basal forebrain networks supporting critical aspects of cognitive function

Findings and Publications

Bilgel M, An Y, Zhou Y, Wong DF, Prince JL, Ferrucci L, Resnick SM. Individual estimates of age at detectable amyloid onset for risk factor assessment. Alzheimers Dement. 2016 Apr;12(4):373-9.

Goh JO, Su YS, Tang YJ, McCarrey AC, Tereshchenko A, Elkins W, Resnick SM. Frontal, Striatal, and Medial Temporal Sensitivity to Value Distinguishes Risk-Taking from Risk-Aversive Older Adults during Decision Making. J Neurosci. 2016 Dec 7;36(49):12498-12509.

Varma VR, Varma S, An Y, Hohman TJ, Seddighi S, Casanova R, Beri A, Dammer EB, Seyfried NT, Pletnikova O, Moghekar A, Wilson MR, Lah JJ, O'Brien RJ, Levey AI, Troncoso JC, Albert MS, Thambisetty M. Alpha-2 macroglobulin in Alzheimer's disease: a marker of neuronal injury through the RCAN1 pathway. Mol Psychiatry. 2017 Jan;22(1):13-23.

Ash JA, Lu H, Taxier LR, Long JM, Yang Y, Stein EA, Rapp PR. Functional connectivity with the retrosplenial cortex predicts cognitive aging in rats. Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12286-12291.

Mayse JD, Nelson GM, Avila I, Gallagher M, Lin SC. Basal forebrain neuronal inhibition enables rapid behavioral stopping. Nat Neurosci. 2015 Oct;18(10):1501-8.


Brain Aging and Behavior Section
         Cognitive Testing Group
Clinical and Translational Neuroscience Section
Neurocognitive Aging Section

Laboratory of Behavioral Neuroscience Staff

Name Title Email
Yang AN Statistician
Lori Beason-Held Staff Scientist
Jafar BHATTI Post Baccalaureate IRTA
Murat BILGEL Staff Scientist
Elizabeth BURKE Psychologist
Nicole CALCAGNO Post Baccalaureate IRTA
Ciana COOPER Post Doc
Angela DABNEY Psychologist
Wendy ELKINS Psychologist
Raul GARCIA ROSARIO Post Baccalaureate IRTA
Melissa KITNER TRIOLO Technical Laboratory Manager
Jeffrey LONG Staff Scientist
Maiya MACALPINE Post Baccalaureate IRTA
Perla MORENO CASTILLA Postdoc Fellow (Visiting Fellow)
Craig MYRUM Postdoc Fellow
Peter RAPP Senior Investigator
Susan RESNICK Chief, Laboratory of Behavioral Neuroscience
Edward RIVERA MELENDEZ Post Baccalaureate (IRTA)
Alyssa RODRIGUEZ Post Baccalaureate (IRTA)
Faysal SHAIKH Postbaccalaureate IRTA
Jong SHIN Post Baccalaureate IRTA
Brandon TARAKU Post Baccalaureate IRTA
Antonio TERRACCIANO Guest Researcher