Laboratory of Behavioral Neuroscience
Susan Resnick, PhD, Chief
The fundamental scientific paradigm guiding research in the Laboratory of Behavioral Neuroscience (LBN) is the study of individual differences and age-related changes in cognition, personality, brain structure and function, and their influences on age-related changes.
The Laboratory of Behavioral Neuroscience
- Conducts basic and clinical research on individual differences in cognition, personality, and affect,
- Investigates the neural contributions to these individual differences,
- Investigates the influence of age on these traits and states and their reciprocal influence on cognitive and mental health, well-being, and adaptation,
- Examines predictors and modifiers of age-related neurodegenerative diseases and age-associated changes in behavior, predispositions, and brain-behavior associations,
- Identifies early markers of Alzheimer’s disease and cognitive decline, and examines factors that promote the maintenance of cognitive health.
Laboratory investigators employ a variety of methods, including experimental, longitudinal, epidemiological, neuroimaging, biomarker, neuropathological, and genetic methods in the analyses of behavioral, psychological, and biological aspects of aging.
List of Portfolio/Research Areas
- Cognitive and brain aging;
- Neuroimaging biomarkers of cognitive decline, impairment and resilience;
- Blood-based biomarkers of cognitive impairment and Alzheimer's Disease using proteomic and metabolomic methods;
- Molecular, cellular, anatomic and imaging approaches in animal models of cognitive aging;
- Non-cholinergic basal forebrain networks supporting critical aspects of cognitive function
Findings and Publications
Bilgel M, An Y, Zhou Y, Wong DF, Prince JL, Ferrucci L, Resnick SM. Individual estimates of age at detectable amyloid onset for risk factor assessment. Alzheimers Dement. 2016 Apr;12(4):373-9.
Goh JO, Su YS, Tang YJ, McCarrey AC, Tereshchenko A, Elkins W, Resnick SM. Frontal, Striatal, and Medial Temporal Sensitivity to Value Distinguishes Risk-Taking from Risk-Aversive Older Adults during Decision Making. J Neurosci. 2016 Dec 7;36(49):12498-12509.
Varma VR, Varma S, An Y, Hohman TJ, Seddighi S, Casanova R, Beri A, Dammer EB, Seyfried NT, Pletnikova O, Moghekar A, Wilson MR, Lah JJ, O'Brien RJ, Levey AI, Troncoso JC, Albert MS, Thambisetty M. Alpha-2 macroglobulin in Alzheimer's disease: a marker of neuronal injury through the RCAN1 pathway. Mol Psychiatry. 2017 Jan;22(1):13-23.
Ash JA, Lu H, Taxier LR, Long JM, Yang Y, Stein EA, Rapp PR. Functional connectivity with the retrosplenial cortex predicts cognitive aging in rats. Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12286-12291.
Mayse JD, Nelson GM, Avila I, Gallagher M, Lin SC. Basal forebrain neuronal inhibition enables rapid behavioral stopping. Nat Neurosci. 2015 Oct;18(10):1501-8.