Functional Epigenomics Unit

Payel Sen, Ph.D.
Stadtman Investigator
Head, Functional Epigenomics Unit
Laboratory of Genetics and Genomics
 

Research interests

• Epigenetics/chromatin biology
• Single-cell genomics
• Senescence and Aging

Team

Payel Sen, Head
Na Yang, Postdoctoral Fellow
Changyou Shi, Postdoctoral Fellow
Lin Wang, Postdoctoral Fellow
James Occean, Postbaccalaureate Fellow

Selected Publications

1. Sen P, Lan Y, Li CY, Sidoli S, Donahue G, Dou Z, Frederick B, Chen Q, Luense LJ, Garcia BA, Dang W, Johnson FB, Adams PD, Schultz DC, Berger SL, Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence. Mol Cell. 73(4):684-698.e8 (2019). PMID: 30773298

2. Yang N, Sen P, The senescent cell epigenome, Aging. 10(11):3590-3609 (2018) PMID: 30391936

3. Dou Z, Ghosh K, Vizioli MG, Zhu J, Sen P, Wangensteen KJ, Simithy J, Lan Y, Lin Y, Zhou Z, Capell BC, Xu C, Xu M, Kieckhaefer JE, Jiang T, Shoshkes-Carmel M, Tanim KMAA, Barber GN, Seykora JT, Millar SE, Kaestner KH, Garcia BA, Adams PD, Berger SL, Cytoplasmic chromatin triggers inflammation in senescence and cancer. Nature. 550(7676):402-406 (2017). PMID: 28976970

4. Sen P, Luo J, Hada A, Hailu SG, Dechassa ML, Persinger J, Brahma S, Paul S, Ranish J, Bartholomew B, Loss of Snf5 Induces Formation of an Aberrant SWI/SNF Complex. Cell Rep. 18(9):2135-2147 (2017). PMID: 28249160

5. Sen P, Shah PP, Nativio R, Berger SL, Epigenetic Mechanisms of Longevity and Aging. Cell. 166(4):822-839 (2016). PMID: 27518561

6. Sen P*, Dang W*, Donahue G, Dai J, Dorsey J, Cao X, Liu W, Cao K, Perry R, Lee JY, Wasko BM, Carr DT, He C, Robison B, Wagner J, Gregory BD, Kaeberlein M, Kennedy BK, Boeke JD, Berger SL, H3K36 methylation promotes longevity by enhancing transcriptional fidelity. Genes Dev. 29(13):1362-76 (2015). PMID: 26159996. *Equal contribution.