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Clinical Core Laboratory & Biorepository

Josephine Egan, MD, Chief
Ajoy Karikkineth, M.D., Staff Clinician

CRC supports clinical investigation by assisting with those aspects of experimental design that deal with acquiring laboratory data and, more recently, their interpretation. CCL also facilitates research from individual NIA investigators that require selected clinical research-quality assays. The CRC processes, labels, catalogs, and stores clinical research samples in the Biorepository, and distributes them to research laboratories around the world, in accordance with College of American Pathology guidelines and current human subject regulatory guidelines. Working in close collaboration with the Manager of CRC, the CRC has implemented new procedures to decrease the time required for sample retrieval, which now occurs within days. CRC also provides a dependable service for DNA/RNA extraction of clinical specimens. Additional laboratory services provided by the Diabetes Section and the CRC are: (1) Bio-Plex cytokine assays designed to quantify multiple cytokines in diverse matrices, (2) ELISA and RIAs of various hormones (insulin, C-peptide, adiponectin, leptin, growth hormone, testosterone), cytokines (CRP, IL-6, TNFs, and their receptors), (3) Glucose determination from oral glucose tolerance testing (OGTT) on all BLSA subjects and insulin tolerance testing (ITT) in translational studies.

Portfolio/Research Areas

  • Core Processing Lab
  • DNA/RNA Lab
  • YSI Glucose Lab
  • Biorepository

Clinical Research Core Staff Listing

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