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Clinical Core Laboratory & Biorepository (CCLB)

Josephine Egan, MD, Chief

Ajoy Karikkineth, M.D., Staff Clinician

Giovanna Fantoni, Ph.D., Faculty Head

CCLB supports clinical investigation by assisting with those aspects of experimental design that deal with acquiring laboratory data and, more recently, their interpretation. CCLB also facilitates research from individual NIA investigators that require selected clinical research-quality assays. The CCLB processes, labels, catalogs, and stores clinical research samples in the Biorepository, and distributes them to research laboratories around the world, in accordance with College of American Pathology guidelines and current human subject regulatory guidelines. Working in close collaboration with the Manager of CRC, the CCLB has implemented new procedures to decrease the time required for sample retrieval, which now occurs within days. CCLB also provides a dependable service for DNA/RNA extraction of clinical specimens. Additional laboratory services provided by the Diabetes Section, CCLB and the CRC are: (1) Simoa HD-1 Analyzer™: a bead-based technology; flexible, robust, and ultra-sensitive immunoassay platform for measuring up to 10-plex biomarkers in diverse matrices, (2) ELISA and RIAs of various hormones (insulin, C-peptide, adiponectin, leptin, growth hormone, testosterone), cytokines (CRP, IL-6, TNFs, and their receptors), (3) Glucose determination from oral glucose tolerance testing (OGTT) on all BLSA subjects and insulin tolerance testing (ITT) in translational studies, (4) Olink (Explore 3072): an innovative proteomic platform for protein biomarker discovery and protein analysis, based on Proximity Extension Assay (PEA) technology, using minimal volumes of serum, plasma, or almost any other type of biological sample. Portfolio/Research Areas: Core Processing Lab DNA/RNA Lab YSI Glucose Lab Biomarker discovery Biorepository Team: Charisma Burrows, Biologist Nat Doegen, Technician Cole Douglass, Technician Sunny Cho, Biologist Mona Patel, Biologist Nader Shehaded, Biologist Wesley Wilson, Biologist .

Portfolio/Research Areas

  • Core Processing Lab
  • DNA/RNA Lab
  • YSI Glucose Lab
  • Biorepository

Team

Name Title Email
Edgar ABARCAR Nurse (Reserach Specialist) abarcareb@mail.nih.gov
Linda ALLIBALOGUN Nurse Practitioner lindahassan.allibalogun@nih.gov
Chee Chia Deputy Clinical Director chiac@grc.nia.nih.gov
Sarah DORAN Health Scientist sarah.doran2@nih.gov
Jarod D'AGOSTINO Health Scientist dagostinojm@mail.nih.gov
Victoria DAVIS Registered Nurse vicky.davis@nih.gov
Giovanna FANTONI Staff Scientist giovanna.fantoni@nih.gov
Kenneth FISHBEIN Staff Scientist fishbeink@mail.nih.gov
Arthur HOLMES Pharmacist arthur.holmes@nih.gov
Ajoy Karikkineth Staff Clinician ajoy.karikkineth@nih.gov
Mary LASSITER Ultrasound Technician lassiterma@grc.nia.nih.gov
Tiffen LOVLER TAPIA Health Scientist tiffen.lovlertapia@nih.gov
Julia MCKELVEY Nurse Specialist (Research) julia.mckelvey@nih.gov
Denise MELVIN Lead Nurse Specialist melvinde@grc.nia.nih.gov
Nicolle MODE Statistician nicolle.mode@nih.gov
Belinda MOORE Program Supoprt Specialist bm214d@nih.gov
Sarah PARK Nurse Specialist (Research) sarah.park@nih.gov
Mona PATEL Biologist patelmk@mail.nih.gov
Oretha POTTS Clinical Protocol Coordinator oretha.potts@nih.gov
Jeannie RUFFOLO Lead Nurse Specialist (Research) ruffolojm@mail.nih.gov
Mary SAM-NWOHA Nurse Specialist (Research) samnwoham@grc.nia.nih.gov
Shepherd SCHURMAN Staff Clinician schurmansh@mail.nih.gov
Sarah SHANNON Pharmacy Technician ss840o@nih.gov
Lisa TUREK Registered Nurse tureklm@mail.nih.gov
Allison UDRIS Psychologist allison.udris@nih.gov