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Chee Chia, M.D., Associate Research Physician

Biography

Chee Chia, M.D., Associate Research Physician Dr. Chia is a board-certified endocrinologist who has been with the National Institute on Aging since 2004. She received her bachelor's and master's degrees in Electrical Engineering from the Massachusetts Institute of Technology and her medical degree from Northwestern University School of Medicine. She completed her postgraduate training in internal medicine at the University of Texas Medical School at Houston and her fellowship training in endocrinology and metabolism at the Johns Hopkins University School of Medicine.

Research Topics

Type 2 diabetes has long been recognized as a cause of accelerated aging but the underlying mechanisms linking diabetes and aging are not well understood. Metabolic dysregulation starts years before the actual clinical diagnosis of type 2 diabetes. Obesity plays a central role in development of metabolic dysregulation and diabetes. Enteroendocrine hormones, two incretins in particular – glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) – play a vital role in metabolism.& GIP, specifically, has been linked to obesity, especially central obesity. GIP secretion is influenced by many inter-related factors such as diet, gut microbiota, and the endocannabinoid system. Understanding the relationships of these and other factors may lead us to delaying or preventing the onset of type 2 diabetes.

Selected Publications

  1. Chia CW, Carlson OD, Liu DD, González-Mariscal I, Santa-Cruz Calvo S, Egan JM (2017).  Incretin Secretion in Humans is under the Influence of Cannabinoid Receptors. Am J Physiol Endocrinol Metab. 313(3):E359-E366.
  2. Fabbri E, Chia CW, Spencer RG, Fishbein KW, Reiter DA, Cameron D, Zane A, Moore ZA, Gonzalez-Freire M, Zoli M, Studenski SA, Kalyani RR, Egan JM, Ferrucci L (2017). Insulin Resistance is Associated with Reduced Mitochondrial Oxidative Capacity Measured by 31P Magnetic Resonance Spectroscopy in Non-Diabetic Participants from the Baltimore Longitudinal Study of Aging. Diabetes. 66(1):170-176.
  3. Chia CW, Shardell M, Tanaka T, Liu DD, Gravenstein KS, Simonsick EM, Egan JM, Ferrucci L (2016). Chronic Low-Calorie Sweetener Use and Risk of Abdominal Obesity among Older Adults: A Cohort Study. PLOS One. 11(11):e0167241
  4. Chia CW, Odetunde JO, Kim W, Carlson OD, Ferrucci L, Egan JM (2014).  GIP Contributes to Islet Tri-Hormonal Abnormalities in Type 2 Diabetes. J Clin Endocrinol Metab. 99(7):2477–2485.
  5. Chia CW, Carlson OD, Kim W, Shin Y, Charles CP, Kim H, Melvin DL, Egan JM (2009). Exogenous Glucose-Dependent Insulinotropic Polypeptide Worsens Post-prandial Hyperglycemia in Type 2 Diabetes. Diabetes. 58(6):1342-9. 

Related Scientific Focus Areas

  1. Clinical Research
  2. Epidemiology

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