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Alzheimer's Disease Administrative Supplements

We are providing the materials below to help grantees interested in NOT-AG-23-032, Notice of Special Interest (NOSI): Administrative Supplement Program to help Develop Alzheimer’s-Focused NIH Grants. The first section includes modified descriptions of how Alzheimer's and Alzheimer's-related dementias are identified for coding purposes at NIH.

NIH Coding definitions for Alzheimer's disease and its related Dementias

Alzheimer's Disease: Includes Alzheimer's disease diagnosis, treatment, etiology, and prevention. Mild cognitive impairment research is perceived by experts as AD prevention research and should be included. Research using an AD population should be looked at closely and typically included.

Related Dementias: The National Plan to Address Alzheimer's disease includes related dementias. It was decided at the category development session to include projects studying both Alzheimer's disease and other dementias. These include: frontotemporal dementia (FTD), Lewy body dementia, and vascular contributions to cognitive impairment and dementia (VCID). The dementias associated with Parkinson's disease and with Down syndrome are included too. Cognitive decline in aging is also relevant to the Alzheimer's disease category.

Related Diseases: Other neurodegenerative diseases, such as Parkinson's disease, are included when Alzheimer's disease is also being studied and when common pathways are described. Macular degeneration studies that describe a common pathway with Alzheimer's disease, such as amyloid beta, are included. Other neurologic diseases, such as Huntington's disease, major depressive disorder, multiple sclerosis, Parkinson's disease, Batten disease, schizophrenia and AIDS dementia, are not included unless also researching Alzheimer's.

Caregiving: Studies on family caregivers of Alzheimer's disease patients, as well as Alzheimer's care in nursing homes, are included. Research on caregiving should be included and treated broadly, even if dementia-specific.

Basic Research: Basic research on neuropathology, cognitive decline, memory loss, amyloid, tau, Lewy bodies, etc. is included, when a relationship to Alzheimer's disease is stated.

The FY 2022 funded research supplements on Alzheimer’s and Alzheimer’s related dementias can be found in NIH Reporter using this link.

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