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Notice of Intent to Publish a Funding Opportunity Announcement for Epigenetic Analysis of Aging as a Risk Factor for Chronic Disease and Degenerative Conditions (U34)

Funding Number: NOT-AG-14-012
Funding Type: NOT
Release Date: March 21, 2014
Expiration Date: January 1, 2019
Web Site: http://grants.nih.gov/grants/guide/notice-files/NOT-AG-14-012.html
Notice Intent Publish Funding Opportunity Announcement Epigenetic Analysis Aging a Risk Factor Chronic Disease Degenerative Conditions U34) Notice Number: NOT-AG-14-012 Key Dates Release Date: March 21, 2014 Related Announcements None Issued National Institute Aging NIA) Purpose National Institute Aging intends promote new initiative publishing Funding Opportunity Announcement FOA) solicit applications research-planning grants biological mechanisms underlie aging-as-a-risk factor chronic diseases degenerative conditions. biological mechanisms are focus this FOA epigenetic modifications. Notice being provided allow potential applicants sufficient time develop meaningful collaborations responsive projects.  FOA expected be published Spring 2014 an expected application due date Fall 2014. FOA utilize U34 Activity Code. Details the planned FOA provided below. Research Initiative Details Notice encourages investigators expertise insights this area geroscience begin consider applying this new FOA. initiative based the observation age the major risk factor most chronic diseases degenerative conditions adults. planning grants lay groundwork make leap this observation - aging the major risk factor - definable biology could explain risk. Taking epigenetics quantifiable human samples, focus on epigenetics the risk" not epigenetics aging" epigenetics disease."  plan successfully such research, applicants assemble multidisciplinary team investigators develop plan collaborations aim understand epigenetic mechanisms aging-as-a-risk-factor chronic diseases degenerative conditions. intended outcomes be evaluation the technical requirements, types epigenetic data, clinical parameters candidate human subjects cohorts populations would lead identification aging-specific epigenetic features contribute the increased risk developing diverse chronic diseases degenerative conditions. Consideration should given the following areas: identification the best available human cohorts based clinical definitions laboratory tests, population composition sex, ethnicity similar epidemiological parameters; suitable tissue samples e.g., blood, muscle, etc.); epigenetic studies diseases and/or degenerative conditions; pilot experiments using existing data published reports epigenetics aging. team these multidisciplinary investigators combine expertise aging biology, epigenetics, bioinformatics, statistics, epidemiology, clinical diagnosis, geriatrics be encouraged. APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: Ronald A. Kohanski, Ph.D. National Institute Aging NIA) Telephone: 301-496-6402 Email: kohansir@mail.nih.gov