Human Cell Reprogramming for Functional Genetics of Alzheimer's Disease (R01)Funding Number: RFA-AG-14-012
Release Date: August 7, 2013
Expiration Date: January 8, 2014
Web Site: http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-14-012.html
The goal of this FOA is to establish functional genotype-phenotype relationships of genes known to cause Alzheimer's disease (AD), genes or genetic variants suspected of altering the risk of AD, and genetic and biological modifiers that contribute to the disease process in neural cells using human pluripotent stem cells (hPSC) and genome editing approaches. Determining the function of AD candidate risk genes and genetic variants, identified in GWAS and other studies, in hPSC derived human neurons and glial cells is expected to identify new gene or cellular networks and molecular targets underlying the etiology of AD.