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Notice of Intent to Publish a Funding Opportunity Announcement for Collaborative Research Infrastructure to Develop Research Strategies to Identify Potential Therapeutic Targets Based on Genetic Factors Influencing Human Life Span and Health Span (U24)

Funding Number: NOT-AG-13-012
Funding Type: NOT
Release Date: May 20, 2013
Expiration Date: January 1, 2019
Web Site: http://grants.nih.gov/grants/guide/notice-files/NOT-AG-13-012.html
Notice Intent Publish Funding Opportunity Announcement Collaborative Research Infrastructure Develop Research Strategies Identify Potential Therapeutic Targets Based Genetic Factors Influencing Human Life Span Health Span U24) Notice Number: NOT-AG-13-012 Key Dates Release Date: 20, 2013   Estimated Publication Date Announcement: June 2013 First Estimated Application Due Date: September 2013  Earliest Estimated Award Date: 2014 Earliest Estimated Start Date: July 2014 Issued National Institute Aging NIA) Purpose Purpose this Notice to indicate intent publish Funding Opportunity Announcement FOA) cooperative agreement applications support collaborative research infrastructure includes multidisciplinary team scientists plan evaluate translational research strategies identify potential therapeutic targets based findings genetic factors influencing human life span health span. the context this FOA, term quot;target identification strategy" refers a concerted set applied research approaches address key step the development new therapeutic preventive interventions repurposing existing ones: identification molecules pathways whose activities be favorably modified such interventions. Crucial types expertise the multidisciplinary team should include genetics, epidemiology, physiology, gerontology, cell biology, biotechnology, statistics, bioinformatics. Activities supported through award include information exchange, database informatics development, pilot studies, analyses existing data sets. Notice being provided allow potential applicants sufficient time evaluate possible approaches developing infrastructure, collaborations, responsive projects. FOA have expected application due date September 2013. NIA expects make award among applications submitted this FOA. FOA utilize U24 activity code. Details the planned FOA provided below. Research Initiative Details U24 infrastructure expected be collaborative nature sufficient breadth scientific expertise, staff time commitment, organizational structure, operational procedures information sharing decision-making complete planning evaluation a number potential target identification strategies within five-year award period. collaborative team should include representatives the fields genetics, epidemiology, physiology, gerontology, cell biology, biotechnology, statistics, bioinformatics and, where appropriate, industry other private sector liaisons. research infrastructure should also develop working relationships staff key information sources facilitate data access exchange, identify utilize resources additional expertise available the institutions the team members needed the project. award should support following activities the multidisciplinary team. relative degree emphasis placed specific aspects these activities depend the variants selected the amount existing relevant information regarding them. 1. Create central resource relevant data computational tools. 2. Identify assess gene variant(s) prospective therapeutic target(s). 3. Evaluate specific target identification strategies. project conduct pilot vivo in vitro studies, analyses existing databases, needed evaluating feasibility value specific methods this purpose. 4. Develop preliminary target identification strategies based one more specific variants. 5. Build curated bioinformatics resource prospective targets. range types specific aspects target identification activities be conducted under U24 expected vary will depend the informatics resources, computational tools, selected variants the amount existing relevant information regarding for planning translational studies. Implementation studies beyond pilot studies exploratory data analyses outside scope this FOA. Support such studies be requested the future through FOAs. New population family studies genetic factors influencing longevity also outside scope this FOA. APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: Nalini Raghavachari, PhD National Institute Aging NIA) Telephone: 301) 435-3048 Fax: 301) 402-1784 Email: Nalini.raghavachari@nih.gov