Secondary Analyses of CALERIE Data Set and Stored Biospecimens to Address Research Questions Related to Effects of Caloric Restriction in Humans and Adherence to Caloric Restriction Interventions (R01)Funding Number: RFA-AG-13-008
Funding Type: RFA
Release Date: August 17, 2012
Expiration Date: October 31, 2012
Web Site: http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-13-008.html
The National Institute on Aging (NIA) invites applications for short-term (up to two years) projects involving secondary analysis of CALERIE (Comprehensive Assessment of Long-term Effects of Restricting Intake of Energy) data set and / or stored biospecimens. The goal of these studies is to test the hypotheses about effects of sustained caloric restriction (CR) on protective and risk factors for aging processes and diseases associated with aging, psychological effects and safety of CR, and other specific candidate hypotheses based on pre-clinical animal and cell culture data on mechanisms affecting aging.Applicants are strongly encouraged to apply tools capturing an integrated, global picture of the effects of CR on multiple systems simultaneously. These approaches may include screening in domains such as the proteome, metabolome, transcriptome, and others.