Potential Effects of Metformin on Aging and Age-Related Conditions: Small-Scale Clinical Studies and Secondary Analysis of Controlled Clinical Studies (R01)
Funding Number: PA-12-271 Funding Type: PA Release Date:August 24, 2012 Expiration Date:January 8, 2016 Web Site:http://grants.nih.gov/grants/guide/pa-files/PA-12-271.html
Emerging data from clinical studies of metformin in a variety of patient populations suggest that it may have other effects, besides being an antihyperglycemic agent, which warrant further attention in translational aging research. The objective of this FOA is to support research projects (R01) that include small-scale physiologic studies in humans or secondary analyses of data and/or stored biospecimens from controlled clinical intervention studies, to increase our understanding about the clinical translational potential of metformin to delay deleterious aging changes or to extend healthy human life span. This includes identification of specific populations particularly likely to benefit, and/or to obtain information on metformins human physiologic and cellular effects that would be useful in identifying novel molecular targets.