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Request for Information: Portfolio Analysis of Alzheimer's Disease Research

Funding Number: NOT-AG-12-003
Funding Type: NOT
Release Date: February 10, 2012
Expiration Date: January 1, 2019
Web Site: http://grants.nih.gov/grants/guide/notice-files/NOT-AG-12-003.html
Request Information: Portfolio Analysis Alzheimer’s Disease Research Notice Number: NOT-AG-12-003 Key Dates Release Date: February 10, 2012 Issued National Institute Aging NIA) Purpose Request Information RFI) for information planning purposes only should be construed a solicitation as obligation the part the Federal Government, National Institutes Health NIH), and/or National Institute Aging.  NIH does intend make any awards based responses this RFI to otherwise pay the preparation any information submitted for Government’s of such information. National Institute Aging, component the National Institutes Health the U.S. Department Health Human Services, seeking input US-based international public private funding agencies organizations supporting Alzheimer’s disease regarding interest contributing the development an International Alzheimer’s Disease Research Portfolio IADRP). Background Alzheimer's disease represents major public health concern.  estimated 24 million people worldwide dementia, majority which thought suffer Alzheimer's disease Ferri CP., et al., 2005, Lancet, 366: 2112-7).  number predicted double 2020 triple 2040.  Although few approved drugs alleviate of symptoms Alzheimer's disease, date are medicines available can delay onset slow progression the disease.  light this looming public health crisis, Alzheimer’s disease becoming research priority a growing number countries. public private funding agencies across world enhance expand support Alzheimer’s disease research is urgent need coordinate funding strategies leverage resources order maximize impact public health avoid duplication effort inefficiency.  Such coordination requires comprehensive assessment the current landscape Alzheimer’s disease research the US internationally.  capture landscape provide inventory the existing investment Alzheimer’s disease research research-related resources, funding agencies need use common language a common classification system. this end, National Institute Aging, lead federal agency research Alzheimer’s disease, collaboration the Alzheimer’s Association, largest non-federal organization supporting Alzheimer’s disease research,  developed common Alzheimer’ s disease research ontology CADRO) a tool classify organize Alzheimer’s disease research portfolios.  CADRO developed a dynamic portfolio analysis tool can used to:   i) capture changing landscape Alzheimer’s disease research funded different agencies,  ii) identify opportunities coordination support Alzheimer’s disease research iii) identify funding gaps well areas overlap within across  funding agencies.   CADRO a three-tier classification organized around seven major categories: Molecular Pathogenesis Pathophysiology Alzheimer’s Disease Diagnosis, Assessment Disease Monitoring Translational Research Clinical Interventions Epidemiology Care, Support Health Economics Alzheimer’s Disease Research Resources Consortia Public Private Partnerships Similar efforts behalf other diseases high public health impact been very productive.  example, National Cancer Institute, through leadership the International Cancer Research Partnership ICRP), developed common framework has successfully used funding agencies support strategic coordination funding efforts cancer. this RFI, NIA seeking expand use the CADRO other federal non-federal agencies supporting Alzheimer’s disease research the US internationally the ultimate goal create International Alzheimer’s Disease Research Portfolio the form a publicly available database.  Submitting Response US-based international funding agencies are interested joining effort should send responses the NIA using contact information presented below.  Responding this RFI not considered a commitment participate the development the IADRP.  Responses be publicly available.  Upon contacting NIA, interested parties receive detailed information this effort order make informed decision their participation.  Please mark responses this RFI identifier NOT-AG-12-003 responding via email. Responses be accepted until April 1st 2012. References: Ferri CP, Prince M, Brayne C, Brodaty H, Fratiglioni L, Ganguli M, Hall K, Hasegawa K, Hendrie H, Huang Y, Jorm A, Mathers C, Menezes PR, Rimmer E, Scazufca M; Alzheimer's Disease International,  Lancet,  2005 Dec 17: 366(9503):2112-7. Inquiries Please direct inquiries to: Lorenzo M. Refolo, PhD National Institute Aging Division Neuroscience Dementias Aging Branch 7201 Wisconsin Ave Gateway Bldg, Suite 350 Bethesda, MD, 20892 20819 express mail) Telephone - 301-594-7576 Email: refolol@mail.nih.gov