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NIA Request for information and comments on possibility of using domesticated dogs to advance the study of aging

Funding Number: NOT-AG-10-003
Funding Type: NOT
Release Date: November 9, 2009
Expiration Date: January 1, 2019
Web Site: http://grants.nih.gov/grants/guide/notice-files/NOT-AG-10-003.html
NIA Request information comments possibility using domesticated dogs advance study aging Notice Number: NOT-AG-10-003 Key Dates Release Date: November 9, 2009 Response Date: December 9, 2009 Issued National Institute Aging NIA), http://www.nia.nih.gov) Request Information RFI) for informational planning purposes only should be construed a solicitation as obligation the part the Federal Government, National Institutes Health NIH), and/or National Institute Aging NIA).  NIA does intend make any awards based responses this RFI to otherwise pay the preparation any information submitted for Government's of such information.  Purpose Objectives NIA soliciting input the scientific community the general public the possibility using domesticated dogs advance study aging. possible of dogs based overlapping features between lives dogs humans, including shared living environments, similarities physiology, pathophysiology chronic diseases which, turn, are similarities medical treatments clinical practices.  Suggestions ideas also welcome intramural NIH scientists staff other NIH Institutes Centers. Background domesticated dog Canis lupus familiaris, including pet feral dogs) shares human environment a greater extent any mammal. Humans pet dogs particular) often inhabit same living spaces, eat same similar foods, take same medicines, experience same clinical interventions, suffer similar chronic diseases, are subject significantly overlapping end-of-life issues. Approximately half the inheritable diseases dogs clinically similar those found humans. are approximately 350 recently-derived domestic breeds developed over approximately 15,000 years selective breeding, most derived within past few hundred years) seven closest-relative wild-dog populations including grey wolf which domesticated dogs derived. are millions pet dogs under veterinary care, therefore extensive medical veterinary) records exist. Recent scientific advances established dog genome is basis comprehensive genetic understanding phenotypes dogs. is substantial breed-to-breed variation aging rates for diseases. Thus, dogs show features health aging are similar those humans, there large populations dogs are genetically homogeneous comparable human populations, thus studies dogs be tractable in humans. better understanding genetic variations health aging dogs benefit pets directly the outcomes should readily translated healthier aging humans. Information Requested NIA seeks information several areas will focus basic and/or translational research will employ domesticated dogs aging research. information gathered be used developing research opportunity extramural investigators promote advance research the development application studies aging using domesticated dogs. NIA seeks information on: Existing data bases repositories contain health, disease behavioral information dogs. Such resources be valuable possible experimental designs research addressing aging the chronic diseases frailty associated aging. NIA seeks information the quality utility these databases, based published unpublished studies. involvement veterinarians, societies and/or pet-owners either laboratory lsquo;field research’ aging dogs various breeds. Field research dogs be understood the equivalent clinical studies involving humans.) Ongoing large-scale small-scale genetic clinical studies dog physiology, pathophysiology, nbsp;diseases and/or behavior home-housed pet) laboratory-housed dogs, especially studies aging conditions which aging a risk-factor. Responses Responses be accepted through December 9, 2009. Interested persons, groups, organizations invited submit responses. These should limited three pages marked this Request Information identifier NOT-AG-10-003. Responses preferred electronic format may e-mailed to kohanskir@mail.nih.gov. you willing do so, please indicate primary affiliation/role the categories listed below: Academia Small Business Pharmaceutical Biotechnology Industry Pet Food Industry Federal Government State Government Healthcare Professional e.g., veterinarian) Patient Advocacy Group Kennel Club Respondents receive email confirmation acknowledging receipt their response, will receive individualized feedback. individual responses remain confidential.  Any identifiers e.g., names, institutions, e-mail addresses, etc.) be removed responses compiled.  Only processed, de-identified results be shared internally scientific working groups convened the NIA, appropriate. nbsp;Nonetheless, proprietary information should submitted. Inquiries Inquiries regarding RFI be directed to: Ronald A. Kohanski, Ph.D. Deputy Director, Division Aging Biology National Institute Aging, NIH 7201 Wisconsin Avenue Suite 2C231 Bethesda, Maryland 20892-9205 Phone: 301-496-6402 Email:  nbsp;kohanskir@mail.nih.gov