Development of Assays for High-Throughput screening for use in Probe and Pre-therapeutic Discovery (R01)
Funding Number: PA-10-213 Funding Type: PA Release Date:June 10, 2010 Expiration Date:September 8, 2013 Web Site:http://grants.nih.gov/grants/guide/pa-files/PA-10-213.html
Purpose. This FOA issued by the NIDDK, NCI, NHLBI, NIA, NIAAA, NIAID, NIDR, NIGMS and NIMH of the National Institutes of Health,encourages Research Project Grant (R01) applications from institutions/organizations that propose the development of assays for high throughput screening (HTS) relevant to processes and diseases specific to its mission with the intent of using them to screen for small molecule compounds that show desired properties as probes for use in advancing knowledge about the relevant target, identifying new targets, or serving as pre-therapeutic leads. The NIH launched a Molecular Libraries and Imaging initiative as part of the NIH Roadmap for Medical Research to establish a network of HTS screening centers which provide access to a large compound library, robotics to carry out the assays, and informatics to interpret the results (http://mli.nih.gov/mli/). This FOA seeks to establish a stream of scientifically and technologically outstanding assays for screening by these and other academic centers. Assays may involve targets indirectly related to disease, but which might provide insight into the biology of relevant diseases. Other targets might be associated with rare and neglected diseases, an area of increasing focus for the NIH (http://www.nih.gov/news/health/may2009/nhgri-20.htm). Assays should be relevant to the scope of the research for at least one of the sponsoring NIH Institutes.
Mechanism of Support. This FOA will utilize the R01 grant mechanism.
Funds Available and Anticipated Number of Awards. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received.