Research and Funding

Funding Opportunities

Administrative Supplements for Pilot Studies on Health Span Measurements in Mice

Funding Number: NOT-AG-09-006
Funding Type: NOT
Release Date: July 28, 2009
Expiration Date: January 1, 2019
Web Site: http://grants.nih.gov/grants/guide/notice-files/NOT-AG-09-006.html
Administrative Supplements Pilot Studies Health Span Measurements Mice Notice Number: NOT-AG-09-006 Key Dates Release Date:  July 28, 2009 Receipt Date: September 1, 2009 Earliest Anticipated Start Date: September 30, 2009 Issued National Institute Aging NIA), http://www.nia.gov) Purpose National Institute Aging NIA) announces availability funds ($520,000 paid over Fiscal Years, 2009-2010) support administrative supplements the existing Nathan Shock Centers Excellence Basic Biology Aging research the development assays tests measure parameters health span during normal aging mice. purpose this program to stimulate research develop validate batteries assays tests can used mouse models quantitative tracking health span parameters normal functioning) mice relate directly aging humans.  particular interest assays measure function response a challenge and/or assays are non-invasive nature can used longitudinally.  Examples assays include, are limited to, response novel vaccines xenobiotics, assays musculoskeletal function such balance, grip strength climbing ability, changes bone strength structure, measurements responsiveness metabolic, cardiovascular respiratory functions response relevant challenges stimuli.  Assays not need serve biomarkers be predictive future health. Background Mouse models contributed greatly our understanding the genetics, biochemistry, physiology normal aging mammals, serve good models many aspects human aging.  Recent studies highlighted importance health span studies aging, especially investigating effects genetic manipulations dietary pharmacological interventions aging mouse models.  Historically, most emphasis been placed lifespan the endpoint determine effects such manipulations.  However, field matured the point where refined analyses needed more quantitatively ascertain health over lifetime mouse models. is need develop pilot assays to generate preliminary data future full-scale studies this topic. Notice aims accelerate pace pilot preliminary research this urgently needed area.        Eligibility current announcement for supplements NIA-supported Centers currently funded under RFA-AG-04-010, Nathan Shock Centers Excellence Basic Biology Aging. Rules: critical Administrative Supplement be considered an administrative supplement, submit request electronically via pdf attachment) in writing NIA, to Division Receipt Referral, Center Scientific Review. request must signed the authorized institutional official describe need additional funding the categorical costs.  Requests under notice should the PHS 398 forms rev. 11/2007; available at: http://grants1.nih.gov/grants/funding/phs398/phs398.html) include following elements the request packet. Font size restrictions apply designated within PHS398 instructions. 1) Cover Letter - Citing Notice, NOT-AG-09-006, the following information: Project Director/Principal Investigator PD/PI) name Parent grant number title Amount the requested supplement Name title the authorized institutional official, Phone, email, address information both PD/PI the institutional official. cover letter must signed the authorized organizational representative. 2) PHS 398 Form Page 1 Face page) MS 81K), PDF 500K) title the project Box 1) should the title the parent award. Notice number title) should cited Box 2, the ldquo;yes” box should checked. Project/Director/Principal Investigator PD/PI) must the same the PD/PI the parent award. Administrative supplements cannot convert grant a single PD/PI a multiple PD/PI grant. remaining items the face page should filled in accordance the PHS 398 application instructions. 3) PHS 398 Form page 2 MS 107K), PDF 313K) Note: project ldquo;summary” that the administrative supplement, the parent grant. other information requested Form Page 2 should provided. 4) brief proposal describing project, including: a) Scope the overall project the anticipated contribution the requested supplement to exceed five pages). section should include description the supplement's specific aims, including research design methods data analysis, well future plans how full development the assays complete testing be done. b) Budget the supplement a justification details items requested, including Administrative costs a justification all personnel their role(s) this project. budget should appropriate the work proposed the supplement request. Applicants encouraged discuss budgets their NIH Program Officer. applications under notice must include detailed budgets the PHS 398 Form Pages 4 MS 82K), PDF 294K)) 5 MS 75K), PDF 141K)). Modular budget pages not accepted. c) Biographical Sketch all new Senior/Key Personnel. is need repeat information previously provided other Senior/Key Personnel. MS PDF d) Human Subjects/ Vertebrate Animal documentation applicable). Include current Vertebrate Animals/IACUC approval letter, available. Otherwise, will required the time funding. appropriate IACUC approvals must in place prior a supplement award being made. Any differences the involvement use vertebrate animals, between administrative supplement activity the parent grant should noted. e) PHS 398 Checklist Form MS 37K), PDF 416K) paragraph must included all Administrative supplements: IMPORTANT:  research proposed the NIH grantee the supplement application must within original scope the NIH-supported grant project.  funding mechanism being used support program, administrative supplements, be used cover cost increases are associated achieving certain new research objectives long they within original scope the project.  Any cost increases need result making modifications the project order take advantage opportunities would increase value the project consistent its originally approved objectives purposes. Submitting Administrative Supplement Request be considered an administrative supplement, requests should sent directly Dr. Felipe Sierra Sierraf@nia.nih.gov) the National Institute Aging, to Division Receipt Referral, Center Scientific Review. request must signed the authorized Business Official describe need additional funding the categorical costs. Requests should also sent Ms. Pamela Adewunmi address below). Selection Factors Administrative supplement requests be reviewed administratively NIA Program Grants Management Staff. Selection factors include following: Relevance the proposed activities the parent grant. Adequate progress the parent grant appropriate the current stage the project. Appropriate well-described plan accomplish goals within timeframe proposed. Expertise the research team proposed conduct achieve goals supplemental study. Budget Funding Information Total funds 520,000, payable over FY2009-2010, be available 2-3 administrative supplements existing Centers.  Administrative supplement requests limited 150,000 total direct costs the time frame the proposed work should exceed active lifetime left the parent grant. is anticipated supplemental funding begin September 2009. to Apply is one-time announcement.  Applications must received or before September 1, 2009.  Submit original, hard copy the request packet original signatures the authorized business official) the NIA address listed below: Grants Management Contact: Pamela Adewunmi Grants Management Branch National Institute Aging National Institutes Health 7201 Wisconsin Ave., Room 2N212 Bethesda, MD 20892-9205 Phone: 301) 496-1472 Fax: 301) 402-3672 EXPRESS/COURIER zip code:   20814 Email: Pamela.Adewunmi@nih.gov not send applications the NIH Center Scientific Review.  addition, applicants encouraged send electronic copy the submitted supplement request an e-mail attachment PDF format the program grants management contacts listed below under ldquo;Inquiries.” Inquiries Inquiries discussion plans responding this Notice strongly encouraged. Please direct inquiries discussions, needed, one the following: Program Contact: Felipe Sierra, Ph.D. National Institute Aging National Institutes Health 7201 Wisconsin Ave., Room 2C231 Bethesda, MD 20892 EXPRESS/COURIER zip code:  20814 Phone: 301) 496-6402 Fax: 301) 402-0010 Email: sierraf@nia.nih.gov  nbsp;