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Precision Medicine Approaches for Developing Combination Therapies for the Treatment and Prevention of Alzheimer's Disease (AD) and AD-Related Dementias

Audience

Researchers interested in pharmacologic and non-pharmacologic interventions for Alzheimer's disease (AD) and AD-related dementias (ADRD) are invited to participate in this workshop.

Dates

December 4, 2023 | 9:00 a.m. - 5:30 p.m. ET

December 5, 2023 | 9:30 a.m. - 12:00 p.m. ET

Location

This hybrid workshop will be available for participants to join virtually through Zoom.

Purpose and Background

This workshop will bring together experts from academia, biotech industry, non-profit foundations, the NIH and the FDA. Presentations from speakers will highlight the current an emerging therapeutic landscape for AD/ADRD and discuss opportunities and challenges for the development of combination therapies for the treatment and prevention of AD/ADRD, including the development of combinations of pharmacologic and non-pharmacologic interventions, as precision medicine therapies.

Registration

Register for this workshop

Agenda

A draft agenda is shown below. Check back for updates.

Note: This agenda is in Eastern Time.

Day 1, Monday, December 4

9:00 a.m. Welcome and Introductions, National Institute on Aging Program Staff

9:15 a.m. Plenary Talks

  • Alzheimer's Disease (AD) and AD-Related Dementias (ADRD) Drug Development Landscape, Jeff Cummings, University of Nevada, Las Vegas
  • Non-Pharrmacologic Interventions for AD/ADRD, Laura Baker, Wake Forest University
  • Deconstructing Disease Complexity to Inform Development of Combination Therapies for AD/ADRD, Nathan Price, Thorne Health Tech

10:15 a.m. Break

10:30 a.m. Session 1 | Modeling Disease Complexity and Establishing Preclinical Proof-of-Concept for Combination Therapy Development, Chair: Marina Sirota, University of California, San Francisco

  • Noam Beckmann, Icahn School of Medicine at Mt. Sinai
  • Yaqiao Li, University of California, San Francisco
  • Cynthia Lemere, Harvard University
  • Eric Siemers, Acumen
  • Q&A/ moderated discussion

12:00 p.m. Lunch Break

1:00 p.m. Session 2 | Systems-based Approaches to Understand the Mechanisms of Action and Responder Phenotypes for Pharmacologic and Non-Pharmacologic Interventions, Chair: Suzana Petanceska, National Institute on Aging

  • Sid O'Bryant, University of North Texas Health Science Center
  • Rima Kaddurah-Daouk, Duke University
  • Mark Mapstone, University of California, Irvine
  • Q&A/ moderated discussion

2:15 p.m. Session 3 | Considerations for Selecting Combination Interventions for Testing in Humans: What to Combine, When and for Whom, Chair: Reisa Sperling, Harvard University

  • Frank Longo, Stanford University
  • Suzanne Craft, Wake Forest University
  • Roberta Diaz Brinton, University of Arizona
  • Reisa Sperling, Harvard University
  • Q&A/ moderated discussion

3:45 p.m. Break

4:00 p.m. Session 4 | Designing Clinical Trials for Testing Combination Therapies/Interventions, Chair: Laura Baker, Wake Forest University

  • Rema Raman, University of Southern California
  • Doris Molina-Henry, University of Southern California
  • Kristine Yaffe, University of California, San Francisco
  • Q&A/ moderated discussion

5:30 p.m. Adjourn Day 1

Day 2, Tuesday, December 5

9:30 a.m. Session 5 | Panel Discussion on Data and Biospecimen Sharing from Clinical Trials Moderator: Laurie Ryan, National Institute on Aging

  • Discussants
  • Laurie Ryan, National Institute on Aging
  • Heather Snyder, Alzheimer's Association
  • Sudhir Sivakumaran, Critical Path for Alzheimer's Disease

10:30 a.m. Session 6 | Regulatory Considerations for the Development of Combination Therapies for AD/ADRD, Teresa Buracchio, Food and Drug Administration

11:00 a.m. Session 7 | Moderated Discussion on Opportunities and Barriers for the Development of Combination Therapies for AD/ADRD

11:50 a.m. Closing remarks

12:00 p.m. Adjourn Day 2

Contact Information

Please contact Dr. Benfeard Williams (benfeard.williams@nih.gov) or Ms. Erika Tarver (erika.tarver@nih.gov) with any questions about the workshop.

Reasonable Accommodation: If you need reasonable accommodation to participate in this event, please contact the meeting organizer listed under Contact information. Please make your request no later than 1 week before the event.

nia.nih.gov

An official website of the National Institutes of Health