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A Joint Workshop of NIA and NIAAA: Role of Alcohol Misuse in the Onset and Progression of Alzheimer’s Disease and Its Related Dementias

Audience

Researchers interested in better understanding how alcohol misuse contributes to the onset and progression of Alzheimer’s disease and its related dementias are invited to participate in this workshop.

Dates

July 26, 2023 | 10 a.m.-4 p.m. ET

July 27, 2023 | 10 a.m.-4 p.m. ET

Location

This hybrid workshop will be available for participants to join virtually through Zoom.

Purpose and Background

The goal of this workshop was to discuss the role of alcohol misuse in the onset and progression of Alzheimer’s disease (AD) and its related dementias (ADRD). This workshop discussed a lifespan perspective of prenatal, adolescent, and late-life alcohol exposure on the development of AD/ADRD. Presentations included information on both preclinical and clinical evidence on how chronic heavy alcohol exposure may intersect with pathways of developing AD/ADRD and exacerbate dementias.

Building on previous funding opportunities and administrative supplements, this workshop facilitated the identification of research gaps and challenges to advance our understanding of the relationship between alcohol misuse and dementias.

Agenda

A draft agenda is shown below. Check back for updates.

Note: This agenda is in Eastern Time.

Day 1 (Wednesday, July 26)

10 a.m. Welcome Remarks, Amy Kelley, National Institute on Aging and George Koob, National Institute on Alcohol Abuse and Alcoholism

10:10 a.m. Workshop Objectives, Lisa Opanashuk, National Institute on Aging and Changhai Cui, National Institute on Alcohol Abuse and Alcoholism

10:20 a.m. Keynote: Neuroimaging signatures of alcohol misuse in the aging brain: implications for dementia, Edith Sullivan, Stanford University

10:50 a.m. Break

Session 1 | Impact of life course alcohol exposure on cognitive decline and dementia. Chair: Lisa Opanashuk, National Institute on Aging

10:55 a.m. Is prenatal alcohol exposure a possible risk factor for the early onset of Alzheimer’s disease? Hermes Yeh, Geisel School of Medicine at Dartmouth

11:10 a.m. Impact of prenatal alcohol on cognitive impairment in a vascular dementia model and a transgenic AD model, Farida Sohrabji, Texas A&M University

11:25 a.m. Age-related changes in alcohol expectancy and anxiety: the effects on problem drinking and neural correlates, Chiang-Shan Li, Yale University

11:40 a.m. Probing early indicators of age-related vulnerability to alcohol, Sara Jo Nixon, University of Florida

11:55 a.m. Q&A/moderated discussion. Moderators: Sara Jo Nixon, University of Florida and Rajesh Miranda, Texas A&M University

12:25 p.m. Lunch

Session 2 | Neuroinflammation in Alzheimer’s disease and alcohol misuse. Chair: Lisa Opanashuk, National Institute on Aging

12:55 p.m. Neuroinflammation in Alzheimer’s disease, Kerry O’Banion, University of Rochester

1:10 p.m. Alcohol promotion of Alzheimer's pathology through immuno-metabolic crosstalk, Leon Coleman, University of North Carolina at Chapel Hill

1:25 p.m. Adolescent binge alcohol exposure enhances Alzheimer’s disease-associated neuropathology in the basal forebrain of adult 5XFAD mice: Reversal through blockade of HMGB1, Ryan Vetreno, University of North Carolina at Chapel Hill

1:40 p.m. NLRP3 inflammasome in the crossroads of alcohol misuse and Alzheimer's disease, Gyongyi Szabo, Harvard Medical School

1:55 p.m. Q&A/moderated discussion. Moderator: Gyongyi Szabo, Harvard Medical School

2:25 p.m. Break

Session 3 | Brain functional dysregulations in alcohol misuse and Alzheimer's disease. Chair: Antonio Noronha, National Institute on Alcohol Abuse and Alcoholism

2:35 p.m. Disentangling the relationship between alcohol consumption, structural brain measures, and genetics, Laura Bierut, Washington University in St. Louis

2:50 p.m. Alcohol interactions with the serotonin system in the early stages of Alzheimer's disease, Catherine Marcinkiewcz, University of Iowa

3:05 p.m. The impact of chronic alcohol consumption on cognitive flexibility in the 5xFAD mouse model of Alzheimer's disease, Jun Wang, Texas A&M University

3:20 p.m. Q&A/moderated discussion. Moderator: Laura Bierut, Washington University in St. Louis

4:00 p.m. Adjourn Day 1

Day 2 (Thursday, July 27)

10 a.m. Welcome

Session 4 | Diverse pathways mediating impacts of alcohol misuse on Alzheimer's disease pathophysiology. Chair: Changhai Cui, National Institute on Alcohol Abuse and Alcoholism

10:05 a.m. Moderate and chronic alcohol exposure alters low-density lipoprotein cholesterol-mediated proinflammatory cytokines, apolipoprotein E, and cognitive function in a sex-dependent manner in APP/PS1 transgenic mice, Doo-Sup Choi, Mayo Clinic

10:20 a.m. Alcohol, mitochondrial oxidant stress, and Alzheimer’s-related pathology, Steven Graves, University of Minnesota

10:35 a.m. Chronic Intermittent ethanol alters cognition and hippocampal protein pathways associated with Alzheimer's disease, Doug Matthews, University of Wisconsin Eau Claire

10:50 a.m. Alcohol, aging, and oligodendrocytes, Heather Richardson, University of Massachusetts

11:05 a.m. Q&A/moderated discussion. Moderators: Doo-Sup Choi, Mayo Clinic and Doug Matthews, University of Wisconsin Eau Claire

11:35 a.m. Break

Session 5 | Cellular mechanisms of Alzheimer’s disease and alcohol misuse. Chair: Changhai Cui, National Institute on Alcohol Abuse and Alcoholism

11:45 a.m. The SEA-AD consortium: Identifying cellular vulnerabilities and disease trajectories in Alzheimer’s disease, Ed Lein, Allen Institute for Brain Science

12:00 p.m. Abeta burden in the brains of those with alcohol-use disorders, Rajesh Narendran, University of Pittsburgh

12:15 p.m. Alcohol, motivation, and tauopathy, Zoe McElligott, University of North Carolina at Chapel Hill

12:30 p.m. Imaging neuroimmune and neurovascular alterations during Alzheimer’s disease progression, Abbas Yaseen, Northeastern University

12:45 p.m. Q&A/moderated discussion. Moderator: Pietro Sanna, Scripps Research Institute

1:15 p.m. Lunch

Session 6 | Central and peripheral interactions in Alzheimer's disease and alcohol misuse. Chair: Peter Gao, National Institute on Alcohol Abuse and Alcoholism

1:45 p.m. Epigenetic aging associated with alcohol use disorder, Falk Lohoff, National Institute on Alcohol Abuse and Alcoholism

2:00 p.m. Network meta-analysis on the molecular mechanisms underlying exposure to alcohol leading to Alzheimer's disease, Sulie L Chang, Seton Hall University

2:15 p.m. Alcohol-induced aldehyde toxicity, ALDH2 deficiency and Alzheimer's disease, Che-Hong Chen, Stanford University

2:30 p.m. Modulation of the liver-brain axis and its impact on Alzheimer’s disease pathology, Derick Han, Keck Graduate Institute

2:45 p.m. Q&A/moderated discussion. Moderator: Greg Sutherland, University of Sydney

3:00 p.m. Break

3:10 p.m. Synthesis by moderators

3:40 p.m. Final discussion, Lisa Opanashuk, National Institute on Aging and Changhai Cui, National Institute on Alcohol Abuse and Alcoholism

3:55 p.m. Closing remarks, Eliezer Masliah, National Institute on Aging

4:00 p.m. Adjourn Day 2

Contact Information

Please contact Dr. Lisa Opanashuk (lisa.opanashuk@nih.gov) or Dr. Changhai Cui (changhai.cui@nih.gov) with any questions about the workshop.

Additional Information

nia.nih.gov

An official website of the National Institutes of Health